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Mouse Anti-CEP68 Recombinant Antibody (CBWJC-2502) (CBMAB-C3572WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2502
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CEP68.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Centrosomal Protein 68
Introduction
CEP68 (Centrosomal Protein 68) is a Protein Coding gene. Diseases associated with CEP68 include Retinitis Pigmentosa 28. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is AKAP6.
Entrez Gene ID
23177
UniProt ID
Q76N32
Alternative Names
Centrosomal Protein 68; KIAA0582; Centrosomal Protein 68kDa; Centrosomal Protein Of 68 KDa; Cep68;
Function
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621).
Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).
Biological Process
Centriole-centriole cohesion Source: UniProtKB
Centrosome cycle Source: UniProtKB
Protein localization to organelle Source: UniProtKB
Cellular Location
Centrosome. Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis.
PTM
Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564). Phosphorylated directly or indirectly by NEK2 (PubMed:24554434). NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143).
Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25704143, PubMed:25503564). Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation (PubMed:25503564).
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For research use only. Not intended for any clinical use.

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