Mouse Anti-CFHR4 Recombinant Antibody (CBXC-1270) (CBMAB-C1537-CQ)

This product is a mouse antibody that recognizes CFHR4. The antibody CBXC-1270 can be used for immunoassay techniques such as: ICFC.
See all CFHR4 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1270

Antibody Isotype

IgG1

Application

ICFC

Basic Information

Immunogen

Sf 21-derived recombinant human Complement Factor H-related 4/CFHR4, Glu20-Glu331, Accession # Q92496

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

A saline solution containing BSA

Preservative

Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Complement Factor H Related 4

Introduction

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.

Entrez Gene ID

10877

UniProt ID

Q92496

Alternative Names

Complement Factor H Related 4; CFHL4; FHR-4; FHR4; Complement Factor H-Related Protein 4; Complement Factor H-Related 4;

Function

Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.

Biological Process

Regulation of complement activation Source: Reactome

Cellular Location

Secreted

PTM

Glycosylated.

References

Cipriani, V., Lorés-Motta, L., He, F., Fathalla, D., Tilakaratna, V., McHarg, S., ... & Clark, S. J. (2020). Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. Nature communications, 11(1), 1-15.

Cipriani, V., de Motta, L. L., He, F., Fathalla, D., McHarg, S., Bayatti, N., ... & Clark, S. J. (2019). Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration. Investigative Ophthalmology & Visual Science, 60(9), 3870-3870.

Pouw, R. B., Brouwer, M. C., Van Beek, A. E., Józsi, M., Wouters, D., & Kuijpers, T. W. (2018). Complement factor H-related protein 4A is the dominant circulating splice variant of CFHR4. Frontiers in immunology, 9, 729.

Lorés-Motta, L., Paun, C. C., Corominas, J., Pauper, M., Geerlings, M. J., Altay, L., ... & De Jong, E. K. (2018). Genome-wide association study reveals variants in CFH and CFHR4 associated with systemic complement activation: implications in age-related macular degeneration. Ophthalmology, 125(7), 1064-1074.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CFHR4 Recombinant Antibody (640212)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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