Mouse Anti-CFHR4 Recombinant Antibody (CBXC-1270) (CBMAB-C1537-CQ)

Name: Mouse Anti-CFHR4 Recombinant Antibody (CBXC-1270)
SKU: CBMAB-C1537-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

CBXC-1270

Antibody Isotype

IgG1

Application

WB, ELISA, IHC, IF, FC

Basic Information

Immunogen

Recombinant human Complement Factor H-related 4/CFHR4 Glu20-Glu331.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	2 μg/ml
IF(ICC)	8-25 μg/ml
FC	0.25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Complement Factor H Related 4

Introduction

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.

Entrez Gene ID

10877

UniProt ID

Q92496

Alternative Names

Complement Factor H Related 4; CFHL4; FHR-4; FHR4; Complement Factor H-Related Protein 4; Complement Factor H-Related 4;

Function

Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.

Biological Process

Regulation of complement activation Source: Reactome

Cellular Location

Secreted

PTM

Glycosylated.

More Infomation

References

Cipriani, V., Lorés-Motta, L., He, F., Fathalla, D., Tilakaratna, V., McHarg, S., ... & Clark, S. J. (2020). Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. Nature communications, 11(1), 1-15.

Cipriani, V., de Motta, L. L., He, F., Fathalla, D., McHarg, S., Bayatti, N., ... & Clark, S. J. (2019). Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration. Investigative Ophthalmology & Visual Science, 60(9), 3870-3870.

Pouw, R. B., Brouwer, M. C., Van Beek, A. E., Józsi, M., Wouters, D., & Kuijpers, T. W. (2018). Complement factor H-related protein 4A is the dominant circulating splice variant of CFHR4. Frontiers in immunology, 9, 729.

Lorés-Motta, L., Paun, C. C., Corominas, J., Pauper, M., Geerlings, M. J., Altay, L., ... & De Jong, E. K. (2018). Genome-wide association study reveals variants in CFH and CFHR4 associated with systemic complement activation: implications in age-related macular degeneration. Ophthalmology, 125(7), 1064-1074.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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