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Mouse Anti-CHD9 Recombinant Antibody (CBWJC-2643) (CBMAB-C3728WJ)

This product is a Mouse antibody that recognizes CHD9. This antibody CBWJC-2643 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CHD9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2643
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chromodomain Helicase DNA Binding Protein 9
Introduction
CHD9 (Chromodomain Helicase DNA Binding Protein 9) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is CHD7.
Entrez Gene ID
80205
UniProt ID
Q3L8U1
Alternative Names
Chromodomain Helicase DNA Binding Protein 9; Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 320 KDa Protein; PPAR-Alpha-Interacting Complex Protein 320 KDa; Chromatin-Related Mesenchymal Modulator; ATP-Dependent Helicase CHD9; Kismet Homolog 2; PRIC320; CHD-9; CReMM; KISH2; Chromodomain-Helicase-DNA-Binding Protein 9;
Function
Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Regulation of lipid metabolic process Source: Reactome
Cellular Location
Nucleus; Cytoplasm
PTM
Phosphorylated on serine and tyrosine residues.

Chen, H., Xu, X., Liu, Z., & Wu, Y. (2021). MiR-22-3p Suppresses Vascular Remodeling and Oxidative Stress by Targeting CHD9 during the Development of Hypertension. Journal of Vascular Research, 58(3), 180-190.

Xia, T., Pan, Z., & Zhang, J. (2020). CircPDZD8 promotes gastric cancer progression by regulating CHD9 via sponging miR-197-5p. Aging (Albany NY), 12(19), 19352.

Alendar, A., Lambooij, J. P., Bhaskaran, R., Lancini, C., Song, J. Y., van Vugt, H., ... & Berns, A. (2020). Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. PloS one, 15(5), e0233394.

Yoo, H., La, H., Lee, E. J., Choi, H. J., Oh, J., Thang, N. X., & Hong, K. (2020). ATP-Dependent Chromatin Remodeler CHD9 Controls the Proliferation of Embryonic Stem Cells in a Cell Culture Condition-Dependent Manner. Biology, 9(12), 428.

Newton, A. H., & Pask, A. J. (2020). CHD9 upregulates RUNX2 and has a potential role in skeletal evolution. BMC molecular and cell biology, 21(1), 1-9.

Xu, L., Peng, H., Huang, X. X., Xia, Y. B., Hu, K. F., & Zhang, Z. M. (2018). Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer. Brazilian Journal of Medical and Biological Research, 51.

Ooga, M., Funaya, S., Hashioka, Y., Fujii, W., Naito, K., Suzuki, M. G., & Aoki, F. (2018). Chd9 mediates highly loosened chromatin structure in growing mouse oocytes. Biochemical and biophysical research communications, 500(3), 583-588.

Guan, B., Ran, X. G., Du, Y. Q., Ren, F., Tian, Y., Wang, Y., & Chen, M. M. (2018). High CHD9 expression is associated with poor prognosis in clear cell renal cell carcinoma. International journal of clinical and experimental pathology, 11(7), 3697.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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