Sign in or Register   Sign in or Register
  |  

Mouse Anti-CHMP5 Recombinant Antibody (CBYY-C3073) (CBMAB-C4516-YY)

This product is mouse antibody that recognizes CHMP5. The antibody CBYY-C3073 can be used for immunoassay techniques such as: WB, IHC
See all CHMP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3073
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human CHMP5 (NP_057494) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Charged Multivesicular Body Protein 5
Entrez Gene ID
UniProt ID
Alternative Names
Cyclin A2; Cyclin-A; CCN1; CCNA; Cyclin-A2; Cyclin A;
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Biological Process
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to muramyl dipeptide Source: UniProtKB
Endosomal transport Source: Reactome
Endosome to lysosome transport Source: Ensembl
ESCRT III complex disassembly Source: ParkinsonsUK-UCL
Late endosome to vacuole transport via multivesicular body sorting pathway Source: GO_Central
Lysosome organization Source: Ensembl
Midbody abscission Source: UniProtKB
Mitotic metaphase plate congression Source: UniProtKB
Multivesicular body assembly Source: ParkinsonsUK-UCL
Multivesicular body sorting pathway Source: UniProtKB
Nucleus organization Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of centrosome duplication Source: UniProtKB
Regulation of mitotic spindle assembly Source: UniProtKB
Regulation of receptor recycling Source: Ensembl
Vesicle budding from membrane Source: GO_Central
Viral budding Source: UniProtKB
Viral life cycle Source: Reactome
Cellular Location
Endosome membrane; Cytosol. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
PTM
ISGylated. Isgylation inhibits its interaction with VTA1.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-CHMP5 Recombinant Antibody (CBYY-C3073)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare