Mouse Anti-CHRNB2 Recombinant Antibody (CBT2244) (V2LY-0625-LY736)

cholinergic receptor, nicotinic, beta 2 (neuronal)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Acetylcholine receptor signaling pathway Source: ARUK-UCL
Associative learning Source: UniProtKB
B cell activation Source: UniProtKB
Behavioral response to nicotine Source: UniProtKB
Calcium ion transport Source: UniProtKB
Central nervous system projection neuron axonogenesis Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Cognition Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Lateral geniculate nucleus development Source: UniProtKB
Learning Source: UniProtKB
Locomotory behavior Source: UniProtKB
Membrane depolarization Source: UniProtKB
Memory Source: UniProtKB
Negative regulation of action potential Source: UniProtKB
Nervous system process Source: UniProtKB
Optic nerve morphogenesis Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of dopamine secretion Source: UniProtKB
Regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
Regulation of dendrite morphogenesis Source: UniProtKB
Regulation of dopamine metabolic process Source: UniProtKB
Regulation of dopamine secretion Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Regulation of synapse assembly Source: UniProtKB
Regulation of synaptic transmission, dopaminergic Source: UniProtKB
Response to acetylcholine Source: ARUK-UCL
Response to cocaine Source: UniProtKB
Response to ethanol Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to nicotine Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Signal transduction Source: UniProtKB
Smooth muscle contraction Source: UniProtKB
Social behavior Source: UniProtKB
Synaptic transmission, cholinergic Source: UniProtKB
Synaptic transmission involved in micturition Source: UniProtKB
Vestibulocochlear nerve development Source: UniProtKB
Visual learning Source: UniProtKB
Visual perception Source: UniProtKB

Postsynaptic cell membrane; Cell membrane

Epilepsy, nocturnal frontal lobe, 3 (ENFL3): An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.

Extracellular: 26-233
Helical: 234-258
Cytoplasmic: 259-265
Helical: 266-284
Extracellular: 285-299
Helical: 300-321
Cytoplasmic: 322-458
Helical: 459-478