Sign in or Register   Sign in or Register
  |  

Mouse Anti-CIP2A Recombinant Antibody (CBXC-2761) (CBMAB-C0145-CQ)

This product is a mouse antibody that recognizes CIP2A. The antibody CBXC-2761 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IHC-P.
See all CIP2A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-2761
Antibody Isotype
IgG2b, κ
Application
WB, FC, IHC, IF, IHC-P

Basic Information

Immunogen
A synthetic peptide made to a C-terminal portion of the human CIP2A protein. [UniProt# Q8TCG1]
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Proliferation Regulating Inhibitor Of Protein Phosphatase 2A
Entrez Gene ID
Human57650
Mouse224171
Rat360711
UniProt ID
HumanQ8TCG1
MouseQ8BWY9
RatD3ZF50
Alternative Names
Cell Proliferation Regulating Inhibitor Of Protein Phosphatase 2A; KIAA1524; Cancerous Inhibitor Of Protein Phosphatase 2A; Cancerous Inhibitor Of PP2A; P90 Autoantigen; Protein CIP2A; P90;
Function
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
Cellular Location
Cytoplasm; Membrane. Slightly concentrates in the perinuclear region (PubMed:12118381).
Topology
Helical: 192-212

Kauko, O., Imanishi, S. Y., Kulesskiy, E., Yetukuri, L., Laajala, T. D., Sharma, M., ... & Westermarck, J. (2020). Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1. Journal of Biological Chemistry, 295(13), 4194-4211.

Liu, C. Y., Huang, T. T., Chen, Y. T., Chen, J. L., Chu, P. Y., Huang, C. T., ... & Tseng, L. M. (2019). Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression. EBioMedicine, 40, 263-275.

Shentu, Y. P., Huo, Y., Feng, X. L., Gilbert, J., Zhang, Q., Liuyang, Z. Y., ... & Liu, R. (2018). CIP2A causes Tau/APP phosphorylation, synaptopathy, and memory deficits in Alzheimer’s disease. Cell reports, 24(3), 713-723.

Zhang, Y., Huang, P., Liu, X., Xiang, Y., Zhang, T., Wu, Y., ... & Liu, Y. (2018). Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. Journal of pharmacological sciences, 137(3), 305-312.

Lucas, C. M., Scott, L. J., Carmell, N., Holcroft, A. K., Hills, R. K., Burnett, A. K., & Clark, R. E. (2018). CIP2A-and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML. Blood advances, 2(9), 964.

Yang, X., Qu, K., Tao, J., Yin, G., Han, S., Liu, Q., & Sun, H. (2018). Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. Biochemical and biophysical research communications, 495(2), 1807-1814.

Zhao, M., Howard, E. W., Parris, A. B., Guo, Z., Zhao, Q., Ma, Z., ... & Yang, X. (2017). Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells. Oncotarget, 8(35), 58847.

Soofiyani, S. R., Hejazi, M. S., & Baradaran, B. (2017). The role of CIP2A in cancer: a review and update. Biomedicine & Pharmacotherapy, 96, 626-633.

Bartalucci, N., Calabresi, L., Balliu, M., Martinelli, S., Rossi, M. C., Villeval, J. L., ... & Vannucchi, A. M. (2017). Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis. Oncotarget, 8(57), 96710.

Huang, Q., Qin, S., Yuan, X., Zhang, L., Ji, J., Liu, X., ... & Liu, Y. (2017). Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A. Oncology reports, 38(1), 598-606.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CIP2A Recombinant Antibody (CBXC-2761)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare