Mouse Anti-CIT Recombinant Antibody (0462) (CBMAB-0462-CN)

Name: Mouse Anti-CIT Recombinant Antibody (0462)
SKU: CBMAB-0462-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

0462

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1569-1597 at the C-terminus of CRIK of mouse.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Horse, Cattle, Dog, Pig

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CIT

Introduction

This gene encodes a serine/threonine-protein kinase that functions in cell division. Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Entrez Gene ID

11113

UniProt ID

O14578

Alternative Names

CITK; CRIK; STK21; MCPH17

Function

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Biological Process

Actomyosin structure organization Source: GO_Central
Generation of neurons Source: UniProtKB
Intracellular signal transduction Source: InterPro
Mitotic cell cycle Source: UniProtKB
Mitotic cytokinesis Source: UniProtKB
Negative regulation of hippo signaling Source: FlyBase
Neuron apoptotic process Source: UniProtKB
Peptidyl-threonine phosphorylation Source: GO_Central
Positive regulation of cytokinesis Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Microcephaly 17, primary, autosomal recessive (MCPH17):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH17 is a severe form characterized by lissencephaly, enlarged ventricles, agenesis of the corpus callosum, cerebellar hypoplasia, and brainstem hypoplasia. Patients manifest delayed psychomotor development, intellectual disability, spasticity, axial hypotonia, and dysmorphic features.

Cong, L., Bai, Z., Du, Y., & Cheng, Y. (2020). Citron rho-interacting serine/threonine kinase promotes HIF1a-CypA signaling and growth of human pancreatic adenocarcinoma. BioMed research international, 2020.

CHEN, H., XIANG, Q., LIU, D., & WEI, Q. (2019). Citron Rho-Interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway. Journal of Southern Medical University, 39(3), 257.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-CIT Recombinant Antibody (CBYY-C0490) (CAT#: CBMAB-C1455-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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