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Mouse Anti-CLCF1 Recombinant Antibody (CBYY-C3258) (CBMAB-C4702-YY)

This product is mouse antibody that recognizes CLCF1. The antibody CBYY-C3258 can be used for immunoassay techniques such as: ELISA, WB
See all CLCF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3258
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant corresponding to aa29-226 from CLCF1 (AAH12939.1) with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Ascites
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cardiotrophin Like Cytokine Factor 1
Entrez Gene ID
23529
UniProt ID
Q9UBD9
Alternative Names
CASP8 And FADD Like Apoptosis Regulator; Caspase-Like Apoptosis Regulatory Protein; CASP8 And FADD-Like Apoptosis Regulator; Cellular FLICE-Like Inhibitory Protein; FADD-Like Antiapoptotic Molecule 1; MACH-Related Inducer Of Toxicity; Caspase-Eight-Related Protein; Inhibitor Of FLICE; Caspase Homolog; CASP8AP1; FLAME-1; I-FLICE; Casper; C-FLIP;
Function
In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.
Biological Process
B cell differentiation Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: Reactome
Negative regulation of neuron apoptotic process Source: BHF-UCL
Positive regulation of astrocyte differentiation Source: BHF-UCL
Positive regulation of B cell proliferation Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of immunoglobulin production Source: BHF-UCL
Positive regulation of isotype switching to IgE isotypes Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Crisponi/Cold-induced sweating syndrome 2 (CISS2):
An autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.

Yokota, S., Matsumae, G., Shimizu, T., Hasegawa, T., Ebata, T., Takahashi, D., ... & Iwasaki, N. (2021). Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway. Bone, 153, 116140.

Lei, M. M. L., & Lee, T. K. W. (2021). Cancer‐Associated Fibroblasts: Orchestrating the Crosstalk Between Liver Cancer Cells and Neutrophils Through the Cardiotrophin‐Like Cytokine Factor 1–Mediated Chemokine (C‐X‐C motif) Ligand 6/TGF‐β Axis. Hepatology, 73(5), 1631-1633.

Chen, X., Li, J., Ye, Y., Huang, J., Xie, L., Chen, J., ... & Ge, J. (2021). Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women. BMC musculoskeletal disorders, 22(1), 1-9.

Laplante, V., Nadeau, U., Rousseau, M., Lesage, S., Gauchat, J. F., & Pasquin, S. (2021). Detection of Cardiotrophin-like Cytokine Factor 1 (CLCF1) by flow cytometry.

Pasquin, S., Tormo, A., Moreau, J., Laplante, V., Sharma, M., Gauchat, J. F., & Rafei, M. (2019). Cardiotrophin-like cytokine factor 1 exhibits a myeloid-biased hematopoietic-stimulating function. Frontiers in immunology, 10, 2133.

Nahlé, S., Pasquin, S., Laplante, V., Rousseau, F., Sharma, M., & Gauchat, J. F. (2019). Cardiotrophin-like cytokine (CLCF1) modulates mesenchymal stem cell osteoblastic differentiation. Journal of Biological Chemistry, 294(32), 11952-11959.

Pasquin, S., Chehboun, S., Dejda, A., Meliani, Y., Savin, V., Warner, G. J., ... & Gauchat, J. F. (2018). Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity. Scientific reports, 8(1), 1-14.

Ge, J. R., Xie, L. H., Chen, J., Li, S. Q., Xu, H. J., Lai, Y. L., ... & Ni, C. B. (2018). Liuwei Dihuang Pill treats postmenopausal osteoporosis with Shen (Kidney) yin deficiency via Janus kinase/signal transducer and activator of transcription signal pathway by up-regulating cardiotrophin-like cytokine factor 1 expression. Chinese journal of integrative medicine, 24(6), 415-422.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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