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Mouse Anti-CLIC5 Recombinant Antibody (1E6) (V2LY-1206-LY228)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IHC-P, IF

Basic Information

Immunogen
CLIC5 (91 a.a. ~ 190 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml
IHC-P3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chloride intracellular channel 5
Entrez Gene ID
53405
UniProt ID
Q9NZA1
Function
Required for normal hearing (PubMed:24781754).

It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity).

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).

Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).
Biological Process
Chloride transport Source: UniProtKB
Female pregnancy Source: ProtInc
Glutathione metabolic process Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Response to stimulus Source: UniProtKB-KW
Sensory perception of sound Source: UniProtKB
Visual perception Source: UniProtKB-KW
Cellular Location
Isoform 1: Cytoplasm; Cytoskeleton; Apical cell membrane; Cell cortex; Membrane. Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Isoform 2: Golgi apparatus; Centrosome. Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome.
Involvement in disease
Deafness, autosomal recessive, 103 (DFNB103):
A form of sensorineural deafness with onset in early childhood. Hearing impairment progresses from mild to severe or even profound before the second decade, and is accompanied by vestibular areflexia.
Topology
Helical: 193-213
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For research use only. Not intended for any clinical use.

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