Mouse Anti-CMAS Recombinant Antibody (C4949) (V2LY-1206-LY346)

Name: Mouse Anti-CMAS Recombinant Antibody (C4949)
SKU: V2LY-1206-LY346
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Pig, Dog, Cattle, Horse

Clone

C4949

Antibody Isotype

IgG1, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 150-163 within an internal region of CMAS of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Pig, Dog, Cattle, Horse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

cytidine monophosphate N-acetylneuraminic acid synthetase

Entrez Gene ID

Human	55907
Mouse	12764
Rat	312826

UniProt ID

Human	Q8NFW8
Mouse	Q99KK2
Rat	P69060

Function

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).

Biological Process

N-acetylneuraminate metabolic process Source: UniProtKB-UniPathway

Cellular Location

Nucleus

More Infomation

References

Urbanek, K., Sutherland, D. M., Orchard, R. C., Wilen, C. B., Knowlton, J. J., Aravamudhan, P., ... & Dermody, T. S. (2020). Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection. Journal of virology, 95(2), e01571-20.

Qu, R., Sang, Q., Wang, X., Xu, Y., Chen, B., Mu, J., ... & Wang, L. (2020). A homozygous mutation in CMAS causes autosomal recessive intellectual disability in a Kazakh family. Annals of Human Genetics, 84(1), 46-53.

O’Day, E. M., Idos, G. E., Hill, C., Chen, J. W., & Wagner, G. (2018). Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. OncoTargets and therapy, 11, 6827.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CMAS Recombinant Antibody (5A2)

Mouse Anti-CMAS Recombinant Antibody (CBXC-1548)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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