Mouse Anti-CMTM4 Recombinant Antibody (CBFYC-1977) (V2LY-1206-LY371)

Name: Mouse Anti-CMTM4 Recombinant Antibody (CBFYC-1977)
SKU: V2LY-1206-LY371
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1977

Application

WB, IP, ELISA

Immunogen

Recombinant CMTM4 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CKLF-like MARVEL transmembrane domain containing 4

Entrez Gene ID

146223

UniProt ID

Q8IZR5

Function

Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

Cellular Location

Membrane

Chui, N. N. Q., Cheu, J. W. S., Yuen, V. W. H., Chiu, D. K. C., Goh, C. C., Lee, D., ... & Wong, C. C. L. (2022). Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell–Mediated Antitumor Immunity Through PD‐L1. Hepatology communications, 6(1), 178-193.

Takeuchi, H., Konnai, S., Maekawa, N., Minato, E., Ichikawa, Y., Kobayashi, A., ... & Ohashi, K. (2020). Expression analysis of canine CMTM6 and CMTM4 as potential regulators of the PD-L1 protein in canine cancers. Frontiers in veterinary science, 7, 330.

Chrifi, I., Louzao-Martinez, L., Brandt, M. M., Van Dijk, C. G., Bürgisser, P. E., Zhu, C., ... & Cheng, C. (2019). CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions. Angiogenesis, 22(1), 75-93.

Xue, H., Li, T., Wang, P., Mo, X., Zhang, H., Ding, S., ... & Han, W. (2019). CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer. Acta Biochimica et Biophysica Sinica, 51(9), 915-924.

Liu, F., Liu, X., Liu, X., Li, T., Zhu, P., Liu, Z., ... & Han, W. (2019). Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility*[S]. Molecular & Cellular Proteomics, 18(6), 1070-1084.

Bei, C., Zhang, Y., Wei, R., Zhu, X., Wang, Z., Zeng, W., ... & Tan, S. (2017). Clinical significance of CMTM4 expression in hepatocellular carcinoma. OncoTargets and therapy, 10, 5439.

Mezzadra, R., Sun, C., Jae, L. T., Gomez-Eerland, R., De Vries, E., Wu, W., ... & Schumacher, T. N. (2017). Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 549(7670), 106-110.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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