Mouse Anti-CNOT6 Recombinant Antibody (C0654) (V2LY-1206-LY472)

Name: Mouse Anti-CNOT6 Recombinant Antibody (C0654)
SKU: V2LY-1206-LY472
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CNOT6 Recombinant Antibody (C0654) (V2LY-1206-LY472) in WB

Effect of HDAC6 knockdown by siRNA on the protein expression of RBPs (CNOT6 and FUS) in parental and TMZ-resistant Pt#3 cells. The results are shown as mean ± SEM for triplicate samples in each group. ...View More

Wu, A. C., Yang, W. B., Chang, K. Y., Lee, J. S., Liou, J. P., Su, R. Y., ... & Chuang, J. Y. (2022). HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells. Journal of Experimental & Clinical Cancer Research, 41(1), 47.

Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

C0654

Application

WB, IP

Immunogen

Recombinant protein corresponding to the C-terminal region of CNOT6 of human.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CCR4-NOT Transcription Complex Subunit 6

Entrez Gene ID

57472

UniProt ID

Q9ULM6

Function

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, no-go decay Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of translation Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus. Predominantly cytoplasmic.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-CNOT6 Recombinant Antibody (CBLC-LY-014) (CAT#: V2LY-1206-LY473)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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