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Mouse Anti-CNOT6 Recombinant Antibody (C0654) (V2LY-1206-LY472)


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Published Data
V2LY-1206-LY472-1
Mouse Anti-CNOT6 Recombinant Antibody (C0654) (V2LY-1206-LY472) in WB
Effect of HDAC6 knockdown by siRNA on the protein expression of RBPs (CNOT6 and FUS) in parental and TMZ-resistant Pt#3 cells. The results are shown as mean ± SEM for triplicate samples in each group. ...View More
Wu, A. C., Yang, W. B., Chang, K. Y., Lee, J. S., Liou, J. P., Su, R. Y., ... & Chuang, J. Y. (2022). HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells. Journal of Experimental & Clinical Cancer Research, 41(1), 47.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Summary

Host Animal
Mouse
Specificity
Human
Clone
C0654
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to the C-terminal region of CNOT6 of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 6
Entrez Gene ID
57472
UniProt ID
Q9ULM6
Function
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, no-go decay Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
Cellular Location
Cytoplasm; Nucleus. Predominantly cytoplasmic.
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For research use only. Not intended for any clinical use.

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