Mouse Anti-COMMD10 Recombinant Antibody (CBWJC-2945) (V2LY-1206-LY723)

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Basic Information

Host Animal
Mouse
Clone
CBWJC-2945
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 96-202 mapping at the C-terminus of COMMD10 of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
COMM Domain Containing 10
Entrez Gene ID
UniProt ID
Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237).

May down-regulate activation of NF-kappa-B (PubMed:15799966).
Cellular Location
Cytoplasm; Nucleus

Yang, M., Wu, X., Li, L., Li, S., Li, N., Mao, M., ... & Guan, J. (2021). COMMD10 inhibits tumor progression and induces apoptosis by blocking NF‐κB signal and values up BCLC staging in predicting overall survival in hepatocellular carcinoma. Clinical and translational medicine, 11(5), e403.

Cohen, K., Mouhadeb, O., Shlomo, S. B., Langer, M., Neumann, A., Erez, N., ... & Varol, C. (2021). COMMD10 is critical for Kupffer cell survival and controls Ly6Chi monocyte differentiation and inflammation in the injured liver. Cell reports, 37(7), 110026.

Fan, Y., Zhang, L., Sun, Y., Yang, M., Wang, X., Wu, X., ... & Guan, J. (2020). Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human. Cancer gene therapy, 27(3), 216-225.

Rasulov, S. (2020). COMMD10 in epithelial sodium channel (ENaC) trafficking (Doctoral dissertation, University of Otago).

Yang, M., Wu, X., Li, L., Li, S., Pan, S., Du, R., ... & Guan, J. (2019). Inflammation-Related Biomarker COMMD10 Values Up BCLC Staging in Individualized Prediction of Overall Survival in Hepatocellular Carcinoma.

Ware, A. W., Cheung, T. T., Rasulov, S., Burstein, E., & McDonald, F. J. (2018). Epithelial Na+ channel: reciprocal control by COMMD10 and Nedd4-2. Frontiers in Physiology, 9, 793.

Yang, S. S., Li, X. M., Yang, M., Ren, X. L., Hu, J. L., Zhu, X. H., ... & Liang, L. (2017). FMNL2 destabilises COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer. British journal of cancer, 117(8), 1164-1175.

Ware, A. W. (2017). COMMD10 regulates protein trafficking (Doctoral dissertation, University of Otago).

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For research use only. Not intended for any clinical use.

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