Mouse Anti-COPS8 Recombinant Antibody (CBWJC-2054) (V2LY-1206-LY785)

Name: Mouse Anti-COPS8 Recombinant Antibody (CBWJC-2054)
SKU: V2LY-1206-LY785
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2054

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 159-184 near the C-terminus of mouse CSN8.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

Entrez Gene ID

Human	10920
Mouse	108679
Rat	363283

UniProt ID

Human	Q99627
Mouse	Q8VBV7
Rat	Q6P4Z9

Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Biological Process

Activation of NF-kappaB-inducing kinase activity Source: UniProtKB
COP9 signalosome assembly Source: InterPro
Negative regulation of cell population proliferation Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome

Cellular Location

Cytoplasm; Nucleus

Sriwastva, M. K., Deng, Z. B., Wang, B., Teng, Y., Kumar, A., Sundaram, K., ... & Zhang, H. G. (2022). Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway. EMBO reports, e53365.

Sun, L. (2021). COPS8 in cutaneous melanoma: an oncogene that accelerates the malignant development of tumor cells and predicts poor prognosis. Bioscience, Biotechnology, and Biochemistry, 85(2), 242-250.

Abdullah, A., Eyster, K. M., Bjordahl, T., Xiao, P., Zeng, E., & Wang, X. (2017). Murine myocardial transcriptome analysis reveals a critical role of COPS8 in the gene expression of Cullin-RING ligase substrate receptors and redox and vesicle trafficking pathways. Frontiers in physiology, 8, 594.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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