Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CORT Recombinant Antibody (8G10) (V2LY-1206-LY817)


See all CORT antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
8G10
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant CORT.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cortistatin
Entrez Gene ID
1325
UniProt ID
O00230
Function
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Chemical synaptic transmission Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Replication fork processing Source: GO_Central
Resolution of meiotic recombination intermediates Source: GO_Central
Cellular Location
Secreted
More Infomation

Valente, R., Alves, L. Q., Nabais, M., Alves, F., Sousa-Pinto, I., Ruivo, R., & Castro, L. F. C. (2021). Convergent Cortistatin losses parallel modifications in circadian rhythmicity and energy homeostasis in Cetacea and other mammalian lineages. Genomics, 113(1), 1064-1070.

Barriga, M., Benitez, R., Robledo, G., Caro, M., O’Valle, F., Campos-Salinas, J., & Delgado, M. (2021). Neuropeptide Cortistatin Regulates Dermal and Pulmonary Fibrosis in an Experimental Model of Systemic Sclerosis. Neuroendocrinology.

Gomez, J. P., Sáez-Mart, P., Jiménez-Vacas, J. M., Pedraza-Arévalo, S., Enrique, G. G., León-González, A. J., ... & Luque, R. M. (2021, May). Potential therapeutic role of somatostatin and cortistatin in prostate cancer. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Chen, W., Liang, J., Fu, Y., Jin, Y., Yan, R., Chi, J., ... & Yin, X. (2020). Cardioprotection of cortistatin against isoproterenol-induced myocardial injury in rats. Annals of Translational Medicine, 8(6).

Qiu, C., Li, J., Luo, D., Chen, X., Qu, R., Liu, T., ... & Liu, Y. (2020). Cortistatin protects against inflammatory airway diseases through curbing CCL2 and antagonizing NF-κB signaling pathway. Biochemical and Biophysical Research Communications, 531(4), 595-601.

Maynard, K. R., Kardian, A., Hill, J. L., Mai, Y., Barry, B., Hallock, H. L., ... & Martinowich, K. (2020). TrkB signaling influences gene expression in cortistatin-expressing interneurons. Eneuro, 7(1).

Valente, R., Alves, L. Q., Nabais, M., Alves, F., Sousa-Pinto, I., Ruivo, R., & Castro, L. F. C. (2020). Differential Cetacea Circadian Rhythmicity is associated with the molecular erosion of Cortistatin. bioRxiv.

Hill, J. L., Jimenez, D. V., Mai, Y., Ren, M., Hallock, H. L., Maynard, K. R., ... & Martinowich, K. (2019). Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability. Brain Structure and Function, 224(1), 471-483.

Ibáñez-Costa, A., Luque, R. M., & Castaño, J. P. (2017). Cortistatin: a new link between the growth hormone/prolactin axis, stress, and metabolism. Growth Hormone & IGF Research, 33, 23-27.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CORT Recombinant Antibody (8G10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry