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Rabbit Anti-MAP3K8 (Phospho-Thr290) Recombinant Antibody (EG785) (CBMAB-EN940-LY)

The product is antibody recognizes COT (Phospho-Thr290). The antibody EG785 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all MAP3K8 (Phospho-Thr290) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG785
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized phosphopeptide derived from human COT around the phosphorylation site of threonine 290 (R-G-TP-E-I).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase Kinase Kinase 8
Introduction
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Entrez Gene ID
Human1326
Mouse26410
Rat116596
UniProt ID
HumanP41279
MouseQ07174
RatQ63562
Alternative Names
Mitogen-Activated Protein Kinase Kinase Kinase 8; Tumor Progression Locus 2; Proto-Oncogene C-Cot; Tpl-2; ESTF; COT; Proto-Oncogene Serine/Threoine Protein Kinase; Augmented In Rheumatoid Arthritis 2; Cot (Cancer Osaka Thyroid) Oncogene; Serine/Threonine-Protein Kinase Cot;
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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