Mouse Anti-CPA4 Recombinant Antibody (1F4) (V2LY-1206-LY921)

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Basic Information

Host Animal
Mouse
Clone
1F4
Application
ELISA, WB, IF
Immunogen
CPA4 (aa260-361) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
carboxypeptidase A4
Entrez Gene ID
UniProt ID
Function
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164).

Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563).
Biological Process
Histone acetylation Source: UniProtKB
Proteolysis Source: GO_Central
Cellular Location
Secreted

Wang, Y., Xie, Y., Niu, Y., Song, P., Liu, Y., Burnett, J., ... & Sun, L. (2021). Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells. International Journal of Medical Sciences, 18(8), 1753.

Wei, C., Zhou, Y., Xiong, Q., Xiong, M., Hou, Y., Yang, X., & Chen, Z. (2021). Comprehensive Analysis of CPA4 as a Poor Prognostic Biomarker Correlated with Immune Cells Infiltration in Bladder Cancer. Biology, 10(11), 1143.

Gao, W., Guo, N., Zhao, S., Chen, Z., Zhang, W., Yan, F., ... & Chi, K. (2020). Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling. Bioscience reports, 40(5).

Moon, Y., Moon, R., Roh, H., Chang, S., Lee, S., & Park, H. (2020). HIF-1α-dependent induction of carboxypeptidase A4 and carboxypeptidase E in hypoxic human adipose-derived stem cells. Molecules and Cells, 43(11), 945.

Shao, Q., Zhang, Z., Cao, R., Zang, H., Pei, W., & Sun, T. (2020). CPA4 promotes EMT in pancreatic cancer via stimulating PI3K-AKT-mTOR signaling. OncoTargets and therapy, 13, 8567.

Handa, T., Katayama, A., Yokobori, T., Yamane, A., Fujii, T., Obayashi, S., ... & Oyama, T. (2019). Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer. International journal of oncology, 54(3), 833-844.

Bademler, S., Ucuncu, M. Z., Tilgen Yasasever, C., Serilmez, M., Ertin, H., & Karanlık, H. (2019). Diagnostic and prognostic significance of carboxypeptidase A4 (CPA4) in breast cancer. Biomolecules, 9(3), 103.

Zhang, H., Hao, C., Wang, H., Shang, H., & Li, Z. (2019). Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma. International Journal of Experimental Pathology, 100(2), 133-138.

Pan, H., Pan, J., Ji, L., Song, S., Lv, H., Yang, Z., & Guo, Y. (2019). Carboxypeptidase A4 promotes cell growth via activating STAT3 and ERK signaling pathways and predicts a poor prognosis in colorectal cancer. International journal of biological macromolecules, 138, 125-134.

Fu, Y., Su, L., Cai, M., Yao, B., Xiao, S., He, Q., ... & Huang, X. (2019). Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway. Molecular carcinogenesis, 58(11), 2026-2039.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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