Mouse Anti-CPT1C Recombinant Antibody (333) (V2LY-1206-LY1009)

Name: Mouse Anti-CPT1C Recombinant Antibody (333)
SKU: V2LY-1206-LY1009
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

333

Application

WB, IHC, IF

Immunogen

CPT1C Fusion Protein (442-793 aa).

Host Species

Mouse

Specificity

Human, Pig

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:1,000
IHC	1:20-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carnitine Palmitoyltransferase 1C

Entrez Gene ID

126129

UniProt ID

Q8TCG5

Function

May play a role in lipid metabolic process.

Biological Process

Carnitine metabolic process Source: GO_Central
Fatty acid beta-oxidation Source: UniProtKB-UniPathway
Fatty acid metabolic process Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl

Cellular Location

Endoplasmic reticulum; Mitochondrion outer membrane; Synapse; Dendrite; Axon. Localized in the soma and dendritic and axonal projections.

Involvement in disease

Spastic paraplegia 73, autosomal dominant (SPG73):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

Topology

Cytoplasmic: 1-52
Helical: 53-75
Mitochondrial intermembrane: 76-103
Helical: 104-126
Cytoplasmic: 127-803

Miralpeix, C., Reguera, A. C., Fosch, A., Casas, M., Lillo, J., Navarro, G., ... & Rodríguez‐Rodríguez, R. (2021). Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. British Journal of Pharmacology, 178(7), 1507-1523.

Zhang, H., Wang, Y., Guan, L., Chen, Y., Chen, P., Sun, J., ... & Bi, H. (2021). Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. Journal of pharmaceutical analysis, 11(3), 340-350.

Chen, P., Zhang, Q., Zhang, H., Gao, Y., Zhou, Y., Chen, Y., ... & Bi, H. (2021). Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function. Journal of Cellular Physiology, 236(2), 958-970.

Ding, Y., Zhang, H., Liu, Z., Li, Q., Guo, Y., Chen, Y., ... & Cui, H. (2021). Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35. Bioengineered, 12(1), 5440-5449.

Wang, Y., Yu, T., Zhou, Y., Wang, S., Zhou, X., Wang, L., ... & Bi, H. (2020). Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging (Albany NY), 12(8), 6733.

Chen, Y., Zhou, Y., Han, F., Zhao, Y., Tu, M., Wang, Y., ... & Bi, H. (2020). A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics, 10(16), 7193.

Wang, Y., Chen, Y., Guan, L., Zhang, H., Huang, Y., Johnson, C. H., ... & Bi, H. (2018). Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death & Differentiation, 25(4), 735-748.

Roa-Mansergas, X., Fadó, R., Atari, M., Mir, J. F., Muley, H., Serra, D., & Casals, N. (2018). CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Scientific reports, 8(1), 1-13.

Chen, Y., Wang, Y., Huang, Y., Zeng, H., Hu, B., Guan, L., ... & Bi, H. (2017). PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis, 38(4), 474-483.

Pozo, M., Rodríguez-Rodríguez, R., Ramírez, S., Seoane-Collazo, P., López, M., Serra, D., ... & Casals, N. (2017). Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C in male mice. Endocrinology, 158(7), 2226-2238.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331) (CAT#: V2LY-1206-LY1007)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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