Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331) (V2LY-1206-LY1007)

Name: Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331)
SKU: V2LY-1206-LY1007
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331) (V2LY-1206-LY1007) in WB

Protein expression of CPT1C is upregulated by p53 hot-spot mutants. The expressional levels of CPT1C and Actin in control (Ctrl) and mutant p53-bearing MCF12A cells were examined by Western Blotting. ...View More

Wang, C. Y., Wang, C. H., Mai, R. T., Chen, T. W., Li, C. W., & Chao, C. H. (2022). Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation contributes to metabolic reprogramming and tumor progression in basal-like breast cancers. Frontiers in Oncology, 12, 940402.

Distributed under Open Access license CC BY 4.0, without modification.

Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331) (V2LY-1206-LY1007) in Immunoblot

miR-200c-deficiency leads to enhanced expression of CPT1C in mammary epithelial cells. The expression of CPT1C and Actin in control (Ctrl) and miR-200c-KO MCF12A cells (MCF12A-Sg1 and MCF12A-Sg2) were examined by immunoblotting. ...View More

Distributed under Open Access license CC BY 4.0, without modification.

Mouse Anti-CPT1C Recombinant Antibody (CBCNC-331) (V2LY-1206-LY1007) in WB

Western blot analysis showing the expression levels of the peroxisomal proteins 70-kDa peroxisomal membrane protein (PMP70), acyl-CoA-binding domain-containing protein 5 (ACBD5), catalase (CAT), peroxin 5 (PEX5), peroxin 19 (PEX19), acyl-CoA oxidase 1 (ACOX1), acyl-CoA oxidase 3 (ACOX3), 3-ketoacyl-CoA thiolase (ACAA1), sterol carrier protein x (SCPx), acyl-CoA synthetase 4 (ACSL4), 3,2-trans-enoyl-CoA isomerase (PECI), and ATP binding cassette subfamily D member 1 (ABCD1), and the mitochondrial proteins voltage-dependent anion-selective channel protein 1 (VDAC1), carnitine palmitoyl transferase 1 (CPT1), cytochrome c oxidase subunit 4 (COXIV), ATP synthase subunit alpha and beta (ATP5A, ATP5B), mitochondrial import receptor subunit (TOM20), and sterol carrier protein 2 (SCP2), representative of at least three independent experiments. ...View More

Valença, I., Ferreira, A. R., Correia, M., Kühl, S., van Roermund, C., Waterham, H. R., ... & Ribeiro, D. (2020). Prostate cancer proliferation is affected by the subcellular localization of MCT2 and accompanied by significant peroxisomal alterations. Cancers, 12(11), 3152.

Distributed under Open Access license CC BY 4.0, without modification.

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-331

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 8-27 within an N-terminal cytoplasmic domain of human CPT1-C.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carnitine Palmitoyltransferase 1C

Entrez Gene ID

126129

UniProt ID

Q8TCG5

Function

May play a role in lipid metabolic process.

Biological Process

Carnitine metabolic process Source: GO_Central
Fatty acid beta-oxidation Source: UniProtKB-UniPathway
Fatty acid metabolic process Source: GO_Central
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl

Cellular Location

Endoplasmic reticulum; Mitochondrion outer membrane; Synapse; Dendrite; Axon. Localized in the soma and dendritic and axonal projections.

Involvement in disease

Spastic paraplegia 73, autosomal dominant (SPG73):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

Topology

Cytoplasmic: 1-52
Helical: 53-75
Mitochondrial intermembrane: 76-103
Helical: 104-126
Cytoplasmic: 127-803

Miralpeix, C., Reguera, A. C., Fosch, A., Casas, M., Lillo, J., Navarro, G., ... & Rodríguez‐Rodríguez, R. (2021). Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. British Journal of Pharmacology, 178(7), 1507-1523.

Zhang, H., Wang, Y., Guan, L., Chen, Y., Chen, P., Sun, J., ... & Bi, H. (2021). Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence. Journal of pharmaceutical analysis, 11(3), 340-350.

Chen, P., Zhang, Q., Zhang, H., Gao, Y., Zhou, Y., Chen, Y., ... & Bi, H. (2021). Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function. Journal of Cellular Physiology, 236(2), 958-970.

Ding, Y., Zhang, H., Liu, Z., Li, Q., Guo, Y., Chen, Y., ... & Cui, H. (2021). Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35. Bioengineered, 12(1), 5440-5449.

Wang, Y., Yu, T., Zhou, Y., Wang, S., Zhou, X., Wang, L., ... & Bi, H. (2020). Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging (Albany NY), 12(8), 6733.

Chen, Y., Zhou, Y., Han, F., Zhao, Y., Tu, M., Wang, Y., ... & Bi, H. (2020). A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics, 10(16), 7193.

Wang, Y., Chen, Y., Guan, L., Zhang, H., Huang, Y., Johnson, C. H., ... & Bi, H. (2018). Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death & Differentiation, 25(4), 735-748.

Roa-Mansergas, X., Fadó, R., Atari, M., Mir, J. F., Muley, H., Serra, D., & Casals, N. (2018). CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Scientific reports, 8(1), 1-13.

Chen, Y., Wang, Y., Huang, Y., Zeng, H., Hu, B., Guan, L., ... & Bi, H. (2017). PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis, 38(4), 474-483.

Pozo, M., Rodríguez-Rodríguez, R., Ramírez, S., Seoane-Collazo, P., López, M., Serra, D., ... & Casals, N. (2017). Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C in male mice. Endocrinology, 158(7), 2226-2238.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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