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Mouse Anti-CR2 Antibody (HB5) (CBMAB-1090CQ)

This product is a mouse antibody that recognizes CR2. The antibody HB5 can be used for immunoassay techniques such as: FC.
See all CR2 antibodies
Published Data
Fig.1 Total B cells were identified by the expression of cd21.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
HB5
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Complement C3d Receptor 2
Introduction
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Diseases associated with CR2 include Immunodeficiency, Common Variable, 7 and Systemic Lupus Erythematosus 9. Among its related pathways are Hematopoietic cell lineage and RANK Signaling in Osteoclasts.
Entrez Gene ID
1380
UniProt ID
P20023
Alternative Names
CR; C3DR; CD21; CVID7; SLEB9
Function
Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047).

Participates in B lymphocytes activation (PubMed:7753047).

(Microbial infection) Acts as a receptor for Epstein-Barr virus.
Biological Process
B cell differentiation Source: UniProtKB
B cell proliferation Source: UniProtKB
Complement activation, alternative pathway Source: ARUK-UCL
Complement activation, classical pathway Source: UniProtKB-KW
Immune response Source: UniProtKB
Regulation of complement activation Source: Reactome
Cellular Location
Cell membrane
Involvement in disease
Systemic lupus erythematosus 9 (SLEB9):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Immunodeficiency, common variable, 7 (CVID7):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 21-971
Helical: 972-999
Cytoplasmic: 1000-1033

Erdei, A., Kovács, K. G., Nagy-Baló, Z., Lukácsi, S., Mácsik-Valent, B., Kurucz, I., & Bajtay, Z. (2021). New aspects in the regulation of human B cell functions by complement receptors CR1, CR2, CR3 and CR4. Immunology Letters, 237, 42-57.

Kovács, K. G., Mácsik-Valent, B., Matkó, J., Bajtay, Z., & Erdei, A. (2021). Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells. Frontiers in immunology, 12.

Ng, H. L., Taylor, R. L., Cheng, J., Abraham, L. J., Quail, E., Cruickshank, M. N., & Ulgiati, D. (2020). Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model. Molecular Immunology, 128, 150-164.

Meza, G., Expósito, A., Royo, J. L., Ruiz-García, C., Sánchez-Arcas, B., Marquez, F. J., ... & Caruz, A. (2020). Association of Complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 Vaccine. AIDS, 34(1), 25-32.

Halkjær, L., Troldborg, A., Pedersen, H., Jensen, L., Hansen, A. G., Hansen, T. K., ... & Thiel, S. (2020). Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans. Frontiers in immunology, 11, 774.

Smith, N. A., Coleman, C. B., Gewurz, B. E., & Rochford, R. (2020). CD21 (Complement Receptor 2) is the receptor for Epstein-Barr virus entry into T cells. Journal of virology, 94(11), e00428-20.

Pekalski, M. L., García, A. R., Ferreira, R. C., Rainbow, D. B., Smyth, D. J., Mashar, M., ... & Wicker, L. S. (2017). Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2. JCI insight, 2(16).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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