Rabbit Anti-CRADD Recombinant Antibody (CBCNC-014) (V2LY-1206-LY1071)

Name: Rabbit Anti-CRADD Recombinant Antibody (CBCNC-014)
SKU: V2LY-1206-LY1071
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBCNC-014

Application

FC, IP, IF, WB

Immunogen

A synthesized peptide derived from human RAIDD.

Host Species

Rabbit

Specificity

Human, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IF(ICC)	1:50-1:200
IP	1:50
FC	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 50% Glycerol, 0.05% BSA

Preservative

0.02% sodium azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CASP2 and RIPK1 domain containing adaptor with death domain

Entrez Gene ID

8738

UniProt ID

P78560

Function

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572).

Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Apoptotic signaling pathway Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: GO_Central
Regulation of apoptotic process Source: Reactome

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Koprulu, M., Shabbir, R. M. K., Zaman, Q., Nalbant, G., Malik, S., & Tolun, A. (2021). CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies. European Journal of Medical Genetics, 64(4), 104181.

Polla, D. L., Rahikkala, E., Bode, M. K., Määttä, T., Varilo, T., Loman, T., ... & Järvelä, I. (2020). Correction: Phenotypic spectrum associated with a CRADD founder variant underlying frontotemporal predominant pachygyria in the Finnish population. European Journal of Human Genetics, 28(4), 532-532.

Järvelä, I., Rahikkala, E., Bode, M. K., Varilo, T., & Norio, R. (2020). Suomalainen tautiperintö laajenee-aivojen paksupoimuisuutta aiheuttava CRADD-geenin mutaatio on rikastunut väestöömme. Duodecim.

Polla, D. L., Rahikkala, E., Bode, M. K., Määttä, T., Varilo, T., Loman, T., ... & Järvelä, I. (2019). Phenotypic spectrum associated with a CRADD founder variant underlying frontotemporal predominant pachygyria in the Finnish population. European Journal of Human Genetics, 27(8), 1235-1243.

Harel, T., Hacohen, N., Shaag, A., Gomori, M., Singer, A., Elpeleg, O., & Meiner, V. (2017). Homozygous null variant in CRADD, encoding an adaptor protein that mediates apoptosis, is associated with lissencephaly. American Journal of Medical Genetics Part A, 173(9), 2539-2544.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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