Mouse Anti-CREB5 (AA 1-99) Recombinant Antibody (CBFYC-2199) (CBMAB-C2269-FY)

This product is mouse antibody that recognizes CREB5. The antibody CBFYC-2199 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all CREB5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYC-2199

Antibody Isotype

IgG2a, k

Application

ELISA, IP, WB

Basic Information

Immunogen

CREB5 (NP_001011666, 1 a.a.-99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MFCTSGGNSA SVMSMRPVPG SLSSLLHLHN RQRQPMPASM PGTLPNPTMP GSSAVLMPME RQMSVNSSIM GMQGPNLSNP CASPQVQPMH SEAKMRLKA

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-99

Target

Full Name

CREB5

Introduction

CREB5 (CAMP Responsive Element Binding Protein 5) is a Protein Coding gene. Among its related pathways are Aldosterone synthesis and secretion and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF2.

Entrez Gene ID

9586

UniProt ID

Q02930

Alternative Names

CAMP Responsive Element Binding Protein 5; CRE-BPA; CREB-5; Cyclic AMP-Responsive Element-Binding Protein 5; CAMP Response Element Binding Protein CRE-Bpa; CAMP Response Element-Binding Protein CRE-BPa; CAMP-Responsive Element-Binding Protein 5; CREBPA

Function

Binds to the cAMP response element and activates transcription.

Biological Process

Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

References

Wang, S., Qiu, J., Liu, L., Su, C., Qi, L., Huang, C., ... & Liao, W. (2020). CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET. Journal of Experimental & Clinical Cancer Research, 39(1), 1-11.

Zhang, X., Xu, Y., Yamaguchi, K., Hu, J., Zhang, L., Wang, J., ... & Chen, W. (2020). Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis. Cancer Cell International, 20(1), 1-11.

Zhang, M., Li, Y., Wang, H., Yu, W., Lin, S., & Guo, J. (2019). LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5. Cancer biology & therapy, 20(4), 524-536.

Wu, J., Wang, S. T., Zhang, Z. J., Zhou, Q., & Peng, B. G. (2018). CREB5 promotes cell proliferation and correlates with poor prognosis in hepatocellular carcinoma. International Journal of Clinical and Experimental Pathology, 11(10), 4908.

Yu, M., Du, G., Xu, Q., Huang, Z., Huang, X., Qin, Y., ... & Lu, C. (2018). Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss. EBioMedicine, 35, 334-344.

He, S., Deng, Y., Liao, Y., Li, X., Liu, J., & Yao, S. (2017). CREB5 promotes tumor cell invasion and correlates with poor prognosis in epithelial ovarian cancer. Oncology Letters, 14(6), 8156-8161.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Mouse Anti-CREB5 Recombinant Antibody (CBYY-C3242)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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