Mouse Anti-CRYGC Recombinant Antibody (CBFYC-2255) (V2LY-1206-LY1327)

Name: Mouse Anti-CRYGC Recombinant Antibody (CBFYC-2255)
SKU: V2LY-1206-LY1327
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2255

Application

ELISA, WB

Immunogen

CRYGC (aa75-174) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

crystallin, gamma C

Entrez Gene ID

1420

UniProt ID

P07315

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Biological Process

Lens development in camera-type eye Source: GO_Central
Visual perception Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Cataract 2, multiple types (CTRCT2):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye.

Zhou, Z., Zhao, L., Guo, Y., Zhuang, J., Zhuo, N., Chen, H., ... & Wang, L. (2022). A Novel Mutation in CRYGC Mutation Associated with Autosomal Dominant Congenital Cataracts and Microcornea. Ophthalmology Science, 2(1), 100093.

Kandaswamy, D. K., Vasantha, K., Graw, J., & Santhiya, S. T. (2020). A novel CRYGC E128* mutation underlying an autosomal dominant nuclear cataract in a south Indian kindred. Ophthalmic Genetics, 41(6), 556-562.

Zhong, Z., Wu, Z., Han, L., & Chen, J. (2017). Novel mutations in CRYGC are associated with congenital cataracts in Chinese families. Scientific reports, 7(1), 1-7.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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