Rabbit Anti-CSRP2 Recombinant Antibody (C2974) (V2LY-0125-LY83)

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Basic Information

Host Animal
Rabbit
Clone
C2974
Application
WB, IHC, IF
Immunogen
Synthetic peptide corresponding to residues surrounding Leu88 of human CRP2 protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)1:100-1:400
WB1:1,000
IHC1:200-1:800

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cysteine And Glycine Rich Protein 2
Entrez Gene ID
UniProt ID
Function
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
Biological Process
Actin cytoskeleton organization Source: GO_Central
Cell differentiation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Muscle tissue development Source: GO_Central
Sarcomere organization Source: GO_Central
Cellular Location
Nucleus

Guru, A., Lite, C., Freddy, A. J., Issac, P. K., Pasupuleti, M., Saraswathi, N. T., ... & Arockiaraj, J. (2021). Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model. Developmental & Comparative Immunology, 114, 103863.

Wang, S., Zhang, Y., Liu, Y., Zheng, R., Wu, Z., Fan, Y., ... & Liu, Y. (2020). Inhibition of CSRP2 promotes leukemia cell proliferation and correlates with relapse in adults with acute myeloid leukemia. OncoTargets and therapy, 13, 12549.

Chen, L., Long, X., Duan, S., Liu, X., Chen, J., Lan, J., ... & Zhou, J. (2020). CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways. Theranostics, 10(24), 11063.

Brown-Clay, J. D., Hoffman, C., Mao, X., Moreau, F., Marani, V., Casellas, C. P., ... & Thomas, C. (2019). Pro-Metastatic Matrix Metalloproteinase Expression is Induced by the Invadopodial and Cytoskeletal Regulators Glycine-and Cysteine-Rich Proteins 1 and 2. Available at SSRN 3352504.

Hoffmann, C., Mao, X., Brown-Clay, J., Moreau, F., Al Absi, A., Wurzer, H., ... & Thomas, C. (2018). Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Scientific reports, 8(1), 1-14.

Kihara, T., Sugimoto, Y., Shinohara, S., Takaoka, S., & Miyake, J. (2017). Cysteine-rich protein 2 accelerates actin filament cluster formation. Plos one, 12(8), e0183085.

Wang, S. J., Wang, P. Z., Gale, R. P., Qin, Y. Z., Liu, Y. R., Lai, Y. Y., ... & Ruan, G. R. (2017). Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics. Oncotarget, 8(22), 35984.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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