Rabbit Anti-CTNNA2 Recombinant Antibody (CBLC285-LY) (V2LY-0125-LY294)

Name: Rabbit Anti-CTNNA2 Recombinant Antibody (CBLC285-LY)
SKU: V2LY-0125-LY294
Rating: 5 (1 reviews)

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Published Data

Rabbit Anti-CTNNA2 Recombinant Antibody (CBLC285-LY) (V2LY-0125-LY294) in WB

Western blot of cerebral cortex and cerebella, dissected without nearby ventricles, of WT and αT-cat KO mice. ...View More

Folmsbee, S. S., Wilcox, D. R., Tyberghein, K., De Bleser, P., Tourtellotte, W. G., van Hengel, J., ... & Gottardi, C. J. (2016). αT-catenin in restricted brain cell types and its potential connection to autism. Journal of molecular psychiatry, 4, 1-13. Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLC285-LY

Application

WB, IP, IF

Immunogen

Synthetic peptide corresponding to the carboxy-terminal sequence of human α-N-Catenin.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000
IP	1:250
IF(ICC)	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol

Preservative

Sodium Azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Catenin Alpha 2

Entrez Gene ID

Human	1496
Mouse	12386
Rat	297357

UniProt ID

Human	P26232
Mouse	Q61301
Rat	D4A6H8

Function

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity).

Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181).

It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181).

It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181).

Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

Biological Process

Axonogenesis Source: UniProtKB
Brain morphogenesis Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell migration Source: GO_Central
Dendrite morphogenesis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Positive regulation of muscle cell differentiation Source: Reactome
Prepulse inhibition Source: UniProtKB
Radial glia guided migration of Purkinje cell Source: UniProtKB
Regulation of neuron migration Source: UniProtKB
Regulation of neuron projection development Source: UniProtKB
Regulation of synapse structural plasticity Source: UniProtKB

Cellular Location

Nucleus; Cell membrane; Cytoskeleton; Cytoplasm; Adherens junction; Axon

Involvement in disease

Cortical dysplasia, complex, with other brain malformations 9 (CDCBM9):
An autosomal recessive disorder characterized by neurodevelopmental delay apparent from early infancy, acquired microcephaly, hypotonic cerebral palsy, inability to ambulate or speak, and intractable seizures. Brain imaging shows pachygyria with severe cortical gray matter thickening, paucity of gyri without an obvious posterior-anterior gradient or focal dysplasias, hypogenesis of the corpus callosum, and cerebellar hypoplasia.

Wen, Y., Lin, A., Zhu, W., Wei, T., Luo, P., Guo, L., & Zhang, J. (2021). Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors. Frontiers in Pharmacology, 12.

Eszlari, N., Bagyura, Z., Millinghoffer, A., Nagy, T., Juhasz, G., Antal, P., ... & Bagdy, G. (2021). Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. Pharmaceuticals, 14(9), 850.

Song, J., Zhang, P., Liu, M., Xie, M., Gao, Z., Wang, X., ... & Liu, R. (2019). Novel-miR-4885 promotes migration and invasion of esophageal Cancer cells through targeting CTNNA2. DNA and cell biology, 38(2), 151-161.

Schaffer, A. E., Breuss, M. W., Caglayan, A. O., Al-Sanaa, N., Al-Abdulwahed, H. Y., Kaymakcalan, H., ... & Gleeson, J. G. (2018). Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nature genetics, 50(8), 1093-1101.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CTNNA2 Matched Antibody Pair (315) (CAT#: APMAB-315LY)

Related Products

CTNNA2 Matched Antibody Pair (315) (CAT#: APMAB-315LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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