Mouse Anti-CUL9 Recombinant Antibody (3F7) (V2LY-0125-LY546)

Name: Mouse Anti-CUL9 Recombinant Antibody (3F7)
SKU: V2LY-0125-LY546
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F7

Application

ELISA, WB

Immunogen

PARC (918-1025aa) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cullin 9

Entrez Gene ID

23113

UniProt ID

Q8IWT3

Function

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696).

Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Biological Process

Microtubule cytoskeleton organization Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
Regulation of mitotic nuclear division Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: InterPro

Cellular Location

Cytoplasm

PTM

In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
Neddylated.

Ortolano, N. A., Romero-Morales, A. I., Rasmussen, M. L., Bodnya, C., Kline, L. A., Joshi, P., ... & Gama, V. (2021). A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models. PloS one, 16(3), e0248000.

Hollville, E., Joers, V., Nakamura, A., Swahari, V., Tansey, M. G., Moy, S. S., & Deshmukh, M. (2020). Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease. Scientific reports, 10(1), 1-13.

Li, Z., & Xiong, Y. (2017). Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene, 36(36), 5212-5218.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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