Mouse Anti-CUX1 Recombinant Antibody (2A10) (V2LY-0125-LY550)
Basic Information
| Application | Note |
| IF(ICC) | 10 μg/mL |
| IHC | 3 μg/mL |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
CDP/Cux p110:
Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
Negative regulation of transcription by RNA polymerase II Source: ProtInc
Positive regulation of dendrite morphogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retrograde transport, vesicle recycling within Golgi Source: Ensembl
An autosomal dominant disorder characterized by global developmental delay associated with mild-to-moderate intellectual disability, hypotonia and short stature in some patients.
As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Related Products
Mouse Anti-CUX1 Recombinant Antibody (CBXC-2545) (CAT#: V2LY-0125-LY553)
Mouse Anti-CUX1 Recombinant Antibody (2D10) (CAT#: V2LY-0125-LY555)
Mouse Anti-CUX1 Recombinant Antibody (CBXC-0627) (CAT#: CBMAB-C4970-CQ)
Mouse Anti-CUX1 Recombinant Antibody (CBFYC-2478) (CAT#: V2LY-0125-LY551)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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