Mouse Anti-CWC27 Recombinant Antibody (CBXC-2222) (V2LY-0125-LY563)

Name: Mouse Anti-CWC27 Recombinant Antibody (CBXC-2222)
SKU: V2LY-0125-LY563
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-2222

Application

WB, IHC

Immunogen

Recombinant protein corresponding to amino acids 145-472 of human CWC27 produced in E. coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA, Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CWC27 Spliceosome Associated Protein Homolog

Entrez Gene ID

10283

UniProt ID

Q6UX04

Function

As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106).

Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).

Biological Process

mRNA splicing, via spliceosome Source: Reactome
Protein folding Source: InterPro
Protein peptidyl-prolyl isomerization Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Retinitis pigmentosa with or without skeletal anomalies (RPSKA):
An autosomal recessive disease characterized by retinal degeneration, brachydactyly, short stature, craniofacial dysmorphism, and neurologic defects. Retinal defects are consistent with retinitis pigmentosa in most patients. Neurologic manifestations include mild-to-moderate intellectual disability and psychomotor retardation.

Busetto, V., Barbosa, I., Basquin, J., Marquenet, E., Hocq, R., Hennion, M., ... & Le Hir, H. (2020). Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes. Nucleic acids research, 48(10), 5670-5683.

Xu, M., Xie, Y. A., Abouzeid, H., Gordon, C. T., Fiorentino, A., Sun, Z., ... & Schorderet, D. F. (2017). Mutations in the spliceosome component CWC27 cause retinal degeneration with or without additional developmental anomalies. The American Journal of Human Genetics, 100(4), 592-604.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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