Rabbit Anti-CXCL12 Recombinant Antibody (CBXS-5374) (V2LY-0125-LY653)

C-X-C Motif Chemokine Ligand 12

Adult locomotory behavior Source: Ensembl
Animal organ regeneration Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Axon guidance Source: GO_Central
Blood circulation Source: ProtInc
Cell adhesion Source: ProtInc
Cell chemotaxis Source: UniProtKB
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to chemokine Source: BHF-UCL
Chemokine (C-X-C motif) ligand 12 signaling pathway Source: BHF-UCL
Chemokine-mediated signaling pathway Source: BHF-UCL
Chemotaxis Source: UniProtKB
Defense response Source: InterPro
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: ProtInc
Induction of positive chemotaxis Source: GO_Central
Integrin activation Source: UniProtKB
Killing of cells of other organism Source: UniProtKB
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Negative regulation of leukocyte tethering or rolling Source: UniProtKB
Neuron migration Source: Ensembl
Positive regulation of axon extension involved in axon guidance Source: Ensembl
Positive regulation of calcium ion import Source: BHF-UCL
Positive regulation of cell adhesion Source: MGI
Positive regulation of cell migration Source: GO_Central
Positive regulation of dopamine secretion Source: Ensembl
Positive regulation of endothelial cell proliferation Source: Ensembl
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of T cell migration Source: MGI
Regulation of actin polymerization or depolymerization Source: ProtInc
Response to heat Source: Ensembl
Response to hypoxia Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to radiation Source: Ensembl
Response to ultrasound Source: Ensembl
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB
Telencephalon cell migration Source: Ensembl
Viral process Source: UniProtKB-KW

Secreted

Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.