Mouse Anti-DACT3 Recombinant Antibody (2A5) (V2LY-0125-LY1061)

Name: Mouse Anti-DACT3 Recombinant Antibody (2A5)
SKU: V2LY-0125-LY1061
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2A5

Application

ELISA, IHC, WB

Immunogen

Recombinant human DACT3 (89-202aa) purified from E. coli.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Dishevelled Binding Antagonist Of Beta Catenin 3

Entrez Gene ID

147906

UniProt ID

Q96B18

Function

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Biological Process

Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm

Gao, Q., Hou, L., Wang, H., & Xun, L. (2022). DACT3 has a tumor‐inhibiting role in acute myeloid leukemia via the suppression of Wnt/β‐catenin signaling by DVL2. Journal of Biochemical and Molecular Toxicology, e23014.

Mamoor, S. (2021). Differential expression of dishevelled binding antagonist of beta catenin 3 in human epithelial ovarian cancer.

Lenoir, M., Martín, R., Torres-Maravilla, E., Chadi, S., González-Dávila, P., Sokol, H., ... & Bermúdez-Humarán, L. G. (2020). Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3. Gut microbes, 12(1), 1826748.

Zhao, H., Yang, L., Han, Y., Li, H., Ling, Z., Wang, Y., ... & Wu, G. (2017). Dact3 inhibits the malignant phenotype of non-small cell lung cancer through downregulation of c-Myb. International Journal of Clinical and Experimental Pathology, 10(12), 11580.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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