Mouse Anti-DDO Recombinant Antibody (3F7) (V2LY-0125-LY1324)

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
3F7
Application
ELISA, WB
Immunogen
DDO (270-369aa) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
D-aspartate oxidase
Entrez Gene ID
UniProt ID
Function
Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.
Biological Process
Aspartate catabolic process Source: UniProtKB
Carboxylic acid metabolic process Source: Reactome
D-amino acid catabolic process Source: UniProtKB
Grooming behavior Source: Ensembl
Hormone metabolic process Source: Ensembl
Insemination Source: Ensembl
Protein localization Source: Reactome
Cellular Location
Peroxisome

Katane, M., Kuwabara, H., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., & Homma, H. (2020). Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans: Its potential use in the determination of free d-glutamate in biological samples. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1868(8), 140442.

Takahashi, S. (2020). d-Aspartate oxidase: Distribution, functions, properties, and biotechnological applications. Applied microbiology and biotechnology, 104(7), 2883-2895.

De Rosa, A., Mastrostefano, F., Di Maio, A., Nuzzo, T., Saitoh, Y., Katane, M., ... & Errico, F. (2020). Prenatal expression of d-aspartate oxidase causes early cerebral d-aspartate depletion and influences brain morphology and cognitive functions at adulthood. Amino Acids, 52(4), 597-617.

Nuzzo, T., Feligioni, M., Cristino, L., Pagano, I., Marcelli, S., Iannuzzi, F., ... & Usiello, A. (2019). Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. Experimental neurology, 317, 51-65.

Katane, M., Kuwabara, H., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., & Homma, H. (2018). Rat d-aspartate oxidase is more similar to the human enzyme than the mouse enzyme. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1866(7), 806-812.

Katane, M., Kanazawa, R., Kobayashi, R., Oishi, M., Nakayama, K., Saitoh, Y., ... & Homma, H. (2017). Structure–function relationships in human D-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1865(9), 1129-1140.

Sacchi, S., Novellis, V. D., Paolone, G., Nuzzo, T., Iannotta, M., Belardo, C., ... & Usiello, A. (2017). Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity. Scientific reports, 7(1), 1-13.

Nuzzo, T., Sacchi, S., Errico, F., Keller, S., Palumbo, O., Florio, E., ... & Usiello, A. (2017). Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients. npj Schizophrenia, 3(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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