Rabbit Anti-DDX24 Recombinant Antibody (EG940) (CBMAB-EN1116-LY)

The product is antibody recognizes DDX24. The antibody EG940 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all DDX24 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG940

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human DDX24.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DEAD-Box Helicase 24

Introduction

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

Entrez Gene ID

57062

UniProt ID

Q9GZR7

Alternative Names

DEAD-Box Helicase 24; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24; DEAD (Asp-Glu-Ala-Asp) Box Helicase 24; DEAD Box Protein 24; EC 3.6.4.13; EC 3.6.1;

Function

ATP-dependent RNA helicase.

Biological Process

RNA metabolic process Source: UniProtKB

Cellular Location

Nucleolus; Membrane

References

Burns, W., Bird, L. M., Heron, D., Keren, B., Ramachandra, D., Thiffault, I., ... & Lyons, M. J. (2021). Syndromic neurodevelopmental disorder associated with de novo variants in DDX23. American Journal of Medical Genetics Part A, 185(10), 2863-2872.

Zhao, C., Li, Y., Qiu, C., Chen, J., Wu, H., Wang, Q., ... & Kong, B. (2021). Splicing Factor DDX23, Transcriptionally Activated by E2F1, Promotes Ovarian Cancer Progression by Regulating FOXM1. Frontiers in oncology, 11, 749144-749144.

Abdullah, S. W., Han, S., Wu, J. E., Zhang, Y., Bai, M., Jin, Y., ... & Guo, H. (2020). The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase. Viruses, 12(12), 1348.

Mao, G., Jin, H., & Wu, L. (2017). DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis. Oncotarget, 8(24), 38937.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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