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Mouse Anti-DEFA1 Recombinant Antibody (A6D4) (CBMAB-D0670-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Defensin Alpha 1 (DEFA1). The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all DEFA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A6D4
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
defensin, alpha 1
Introduction
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. DEFA1 is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Entrez Gene ID
1667
UniProt ID
P59665
Alternative Names
Defensin Alpha 1; Defensin, Alpha 1, Myeloid-Related Sequence; Defensin, Alpha 2; Defensin, Alpha 1; DEFA2; HNP-1; DEF1;
Function
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to fungus Source: UniProtKB-KW
Defense response to Gram-negative bacterium Source: GO_Central
Defense response to Gram-positive bacterium Source: UniProtKB
Defense response to protozoan Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Innate immune response in mucosa Source: UniProtKB
Intracellular estrogen receptor signaling pathway Source: UniProtKB
Killing by host of symbiont cells Source: UniProtKB
Killing of cells of other organism Source: UniProtKB
Membrane disruption in other organism Source: GO_Central
Neutrophil degranulation Source: Reactome
Pore formation in membrane of other organism during symbiotic interaction Source: UniProtKB
T cell chemotaxis Source: UniProtKB
Cellular Location
Secreted
PTM
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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