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Mouse Anti-DGKI Recombinant Antibody (CBYCD-255) (CBMAB-D0792-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Diacylglycerol Kinase Iota (DGKI). The antibody can be used for immunoassay techniques, such as WB.
See all DGKI antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYCD-255
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human DGK-iota, Ser925-Val1065 (predicted), Accession # O75912
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Diacylglycerol Kinase Iota
Introduction
DGKI is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration.
Entrez Gene ID
Human9162
Mouse320127
UniProt ID
HumanO75912
MouseD3YWQ0
Alternative Names
Diacylglycerol Kinase Iota; Diglyceride Kinase Iota; DAG Kinase Iota; EC 2.7.1.107; DGK-IOTA;
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9830018, PubMed:23949095).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018).

By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity).
Biological Process
Diacylglycerol metabolic process Source: GO_Central
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: BHF-UCL
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Synaptic cell membrane; Nucleus; Cytosol; Axon; Dendrite; Presynapse; Postsynapse; Postsynaptic density; Synaptic vesicle membrane. Excluded from inhibitory synapses (By similarity). Localization between cytoplasm and nucleus is regulated by protein kinase C (PubMed:9830018). Both in the detergent soluble and particulate fractions (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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