Mouse Anti-DIRAS3 Recombinant Antibody (1218) (V2LY-0425-LY362)

Name: Mouse Anti-DIRAS3 Recombinant Antibody (1218)
SKU: V2LY-0425-LY362
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1218

Antibody Isotype

IgG

Application

ELISA, IP, WB

Basic Information

Immunogen

Recombinant full length of human ARHI protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000
ELISA	1:2,000-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DIRAS Family GTPase 3

Entrez Gene ID

9077

UniProt ID

O95661

Biological Process

Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of gene expression by genetic imprinting Source: ProtInc
Small GTPase mediated signal transduction Source: ProtInc

Cellular Location

Cell membrane

More Infomation

References

Bildik, G., Liang, X., Sutton, M. N., Bast, R. C., & Lu, Z. (2022). DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy. Molecular Cancer Therapeutics, 21(1), 25-37.

Mao, W., Peters, H. L., Sutton, M. N., Orozco, A. F., Pang, L., Yang, H., ... & Bast Jr, R. C. (2019). The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3‐induced dormant ovarian cancer xenografts. Cancer, 125(8), 1267-1280.

Li, X., Liu, S., Fang, X., He, C., & Hu, X. (2019). The mechanisms of DIRAS family members in role of tumor suppressor. Journal of cellular physiology, 234(5), 5564-5577.

Sutton, M. N., Lu, Z., Li, Y. C., Zhou, Y., Huang, T., Reger, A. S., ... & Bast Jr, R. C. (2019). DIRAS3 (ARHI) blocks RAS/MAPK signaling by binding directly to RAS and disrupting RAS clusters. Cell reports, 29(11), 3448-3459.

Sutton, M. N. (2017). The Role of the DIRAS Family Members in Regulating Ras Function, Cancer Growth and Autophagy.

Nowak, E. M., Poczęta, M., Bieg, D., & Bednarek, I. (2017). DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells. Ginekologia Polska, 88(10), 543-551.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DIRAS3 Recombinant Antibody (1218)

Related Products

Mouse Anti-DIRAS3 Recombinant Antibody (1218)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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