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Rabbit Anti-DLEC1 Recombinant Antibody (EG967) (CBMAB-EN1149-LY)

The product is antibody recognizes DLEC1. The antibody EG967 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000.
See all DLEC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG967
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human DLEC1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Deleted In Lung And Esophageal Cancer 1
Introduction
The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]
Entrez Gene ID
9940
UniProt ID
Q9Y238
Alternative Names
Deleted In Lung And Esophageal Cancer 1; Cilia And Flagella Associated Protein 81; DLC-1; DLC1; Deleted In Lung And Esophageal Cancer Protein 1; Deleted In Lung Cancer Protein 1; CFAP81; F56;
Function
Essential for spermatogenesis and male fertility (By similarity).

May play an important role in sperm head and tail formation (By similarity).

May act as a tumor suppressor by inhibiting cell proliferation.
Biological Process
Cell differentiation Source: UniProtKB-KW
Defense response to tumor cell Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Spermatogenesis Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).
Lung cancer (LNCR):
The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer. A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Esophageal cancer (ESCR):
The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription may be implicated in the development of esophageal cancer.
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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