Rabbit Anti-DLEC1 Recombinant Antibody (EG967) (CBMAB-EN1149-LY)

Name: Rabbit Anti-DLEC1 Recombinant Antibody (EG967)
SKU: CBMAB-EN1149-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG967

Application

IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from N-terminal of human DLEC1.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Deleted In Lung And Esophageal Cancer 1

Introduction

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

Entrez Gene ID

9940

UniProt ID

Q9Y238

Alternative Names

Deleted In Lung And Esophageal Cancer 1; Cilia And Flagella Associated Protein 81; DLC-1; DLC1; Deleted In Lung And Esophageal Cancer Protein 1; Deleted In Lung Cancer Protein 1; CFAP81; F56;

Function

Essential for spermatogenesis and male fertility (By similarity).

May play an important role in sperm head and tail formation (By similarity).

May act as a tumor suppressor by inhibiting cell proliferation.

Biological Process

Cell differentiation Source: UniProtKB-KW
Defense response to tumor cell Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Spermatogenesis Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).
Lung cancer (LNCR):
The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer. A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Esophageal cancer (ESCR):
The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription may be implicated in the development of esophageal cancer.
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.

Okitsu, Y., Nagano, M., Yamagata, T., Ito, C., Toshimori, K., Dohra, H., ... & Yogo, K. (2020). Dlec1 is required for spermatogenesis and male fertility in mice. Scientific reports, 10(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DLEC1 Recombinant Antibody (EG967) (CAT#: V2LY-0425-LY429)

Related Products

Mouse Anti-DLEC1 Recombinant Antibody (EG967) (CAT#: V2LY-0425-LY429)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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