Mouse Anti-DLX6 Recombinant Antibody (2D7) (CBMAB-1523-CN)

Name: Mouse Anti-DLX6 Recombinant Antibody (2D7)
SKU: CBMAB-1523-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D7

Application

WB, ELISA, IP

Immunogen

Amino acids 71-160 representing partial length of human Dlx-6.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

distal-less homeobox 6

Introduction

The homeobox transcription factor family is comprised of at least 6 different members with roles in forebrain and craniofacial development. DLX6 is a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene.

Entrez Gene ID

1750

UniProt ID

P56179

Alternative Names

homeobox protein DLX-6; distal-less homeo box 6

Biological Process

Anatomical structure formation involved in morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Embryonic limb morphogenesis Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Head development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of epithelial cell proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal system development Source: ProtInc

Cellular Location

Nucleus

Mullen, R. D., Bellessort, B., Levi, G., & Behringer, R. D. (2022). Distal-less homeobox genes Dlx5/6 regulate Mulllerian duct regression. bioRxiv.

Kong, L., & Zhang, C. (2020). LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p. Cancer Cell International, 20(1), 1-12.

Tian, S., Liu, J., Kong, S., & Peng, L. (2020). LncRNA DLX6-AS1 as a potential molecular biomarker in the clinicopathology and prognosis of various cancers: a meta-analysis. Bioscience Reports, 40(8).

Hu, X., Xiang, Z., Zhang, W., Yu, Z., Xin, X., Zhang, R., ... & Yuan, Q. (2020). Protective effect of DLX6-AS1 silencing against cerebral ischemia/reperfusion induced impairments. Aging (Albany NY), 12(22), 23096.

Fu, X., Tian, Y., Kuang, W., Wen, S., & Guo, W. (2019). Long non‑coding RNA DLX6‑AS1 silencing inhibits malignant phenotypes of gastric cancer cells. Experimental and therapeutic medicine, 17(6), 4715-4722.

Wang, X., Lin, Y., & Liu, J. (2019). Long non‑coding RNA DLX6‑AS1 promotes proliferation by acting as a ceRNA targeting miR‑199a in cervical cancer. Molecular medicine reports, 19(2), 1248-1255.

Zhang, X., Guo, H., Bao, Y., Yu, H., Xie, D., & Wang, X. (2019). Exosomal long non‑coding RNA DLX6‑AS1 as a potential diagnostic biomarker for non‑small cell lung cancer. Oncology letters, 18(5), 5197-5204.

Wang, M., Li, Y., Yang, Y., Liu, X., Zang, M., Li, Y., ... & Zhang, S. (2019). Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma. Molecular medicine reports, 19(3), 1942-1950.

Zhang, N., Meng, X., Mei, L., Zhao, C., & Chen, W. (2019). LncRNA DLX6‐AS1 promotes tumor proliferation and metastasis in osteosarcoma through modulating miR‐641/HOXA9 signaling pathway. Journal of cellular biochemistry, 120(7), 11478-11489.

Huang, Y., Ni, R., Wang, J., & Liu, Y. (2019). Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer. Biomedicine & Pharmacotherapy, 109, 1851-1859.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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