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Mouse Anti-DLX6 Recombinant Antibody (2D7) (CBMAB-1523-CN)

This product is a mouse antibody that recognizes DLX6 of human. The antibody 2D7 can be used for immunoassay techniques such as: WB, ELISA.
See all DLX6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Immunogen
DLX6 (XP_376652, aa. 71-160) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
distal-less homeobox 6
Introduction
The homeobox transcription factor family is comprised of at least 6 different members with roles in forebrain and craniofacial development. DLX6 is a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene.
Entrez Gene ID
1750
UniProt ID
P56179
Alternative Names
homeobox protein DLX-6; distal-less homeo box 6
Biological Process
Anatomical structure formation involved in morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Embryonic limb morphogenesis Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Head development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of epithelial cell proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal system development Source: ProtInc
Cellular Location
Nucleus

Mullen, R. D., Bellessort, B., Levi, G., & Behringer, R. D. (2022). Distal-less homeobox genes Dlx5/6 regulate Mulllerian duct regression. bioRxiv.

Kong, L., & Zhang, C. (2020). LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p. Cancer Cell International, 20(1), 1-12.

Tian, S., Liu, J., Kong, S., & Peng, L. (2020). LncRNA DLX6-AS1 as a potential molecular biomarker in the clinicopathology and prognosis of various cancers: a meta-analysis. Bioscience Reports, 40(8).

Hu, X., Xiang, Z., Zhang, W., Yu, Z., Xin, X., Zhang, R., ... & Yuan, Q. (2020). Protective effect of DLX6-AS1 silencing against cerebral ischemia/reperfusion induced impairments. Aging (Albany NY), 12(22), 23096.

Fu, X., Tian, Y., Kuang, W., Wen, S., & Guo, W. (2019). Long non‑coding RNA DLX6‑AS1 silencing inhibits malignant phenotypes of gastric cancer cells. Experimental and therapeutic medicine, 17(6), 4715-4722.

Wang, X., Lin, Y., & Liu, J. (2019). Long non‑coding RNA DLX6‑AS1 promotes proliferation by acting as a ceRNA targeting miR‑199a in cervical cancer. Molecular medicine reports, 19(2), 1248-1255.

Zhang, X., Guo, H., Bao, Y., Yu, H., Xie, D., & Wang, X. (2019). Exosomal long non‑coding RNA DLX6‑AS1 as a potential diagnostic biomarker for non‑small cell lung cancer. Oncology letters, 18(5), 5197-5204.

Wang, M., Li, Y., Yang, Y., Liu, X., Zang, M., Li, Y., ... & Zhang, S. (2019). Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma. Molecular medicine reports, 19(3), 1942-1950.

Zhang, N., Meng, X., Mei, L., Zhao, C., & Chen, W. (2019). LncRNA DLX6‐AS1 promotes tumor proliferation and metastasis in osteosarcoma through modulating miR‐641/HOXA9 signaling pathway. Journal of cellular biochemistry, 120(7), 11478-11489.

Huang, Y., Ni, R., Wang, J., & Liu, Y. (2019). Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer. Biomedicine & Pharmacotherapy, 109, 1851-1859.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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