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Mouse Anti-DNAI1 Recombinant Antibody (70.1) (CBMAB-D1248-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynein Axonemal Intermediate Chain 1 (DNAI1). The antibody can be used for immunoassay techniques, such as WB, ELISA, IHC-P, FuncS, ICC, Dot, Inhib, ICC, IF.
See all DNAI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Chicken, Hamster, Zebrafish
Clone
70.1
Antibody Isotype
IgM
Application
WB, ELISA, IHC-P, FuncS, ICC, Dot, Inhib, ICC, IF

Basic Information

Specificity
Human, Rat, Chicken, Hamster, Zebrafish
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Axonemal Intermediate Chain 1
Introduction
DNAI1 belongs to the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome.
Entrez Gene ID
Human27019
Chicken431654
Rat500442
Hamster101836467
Zebrafish570363
UniProt ID
HumanQ9UI46
ChickenF1NB77
RatQ5XIL8
HamsterA0A1U8CHA6
ZebrafishE9QFM9
Alternative Names
Dynein Axonemal Intermediate Chain 1; Dynein, Axonemal, Intermediate Polypeptide 1; Testis Tissue Sperm-Binding Protein Li 87P; Dynein Intermediate Chain 1, Axonemal; Axonemal Dynein Intermediate Chain 1; Immotile Cilia Syndrome 1;
Function
Part of the dynein complex of respiratory cilia.
Biological Process
Cilium movement Source: SYSCILIA_CCNET
Determination of left/right symmetry Source: SYSCILIA_CCNET
Epithelial cilium movement involved in extracellular fluid movement Source: Ensembl
Flagellated sperm motility Source: SYSCILIA_CCNET
Heart development Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Microtubule-based movement Source: GO_Central
Outer dynein arm assembly Source: SYSCILIA_CCNET
Cellular Location
Cilium axoneme; Dynein axonemal particle
Involvement in disease
Ciliary dyskinesia, primary, 1 (CILD1):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Kartagener syndrome (KTGS):
An autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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