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Mouse Anti-DPM1 Recombinant Antibody (A-5) (CBMAB-D1559-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic (DPM1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DPM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dolichol-phosphate (beta-D) mannosyltransferase 1
Introduction
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in DPM1 are associated with congenital disorder of glycosylation type Ie.
Entrez Gene ID
8813
UniProt ID
O60762
Alternative Names
Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic; Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 1; Dolichol-Phosphate Mannose Synthase Subunit 1; DPM Synthase Complex, Catalytic Subunit; Mannose-P-Dolichol Synthase Subunit 1; DPM Synthase Subunit 1; MPD Synthase Subunit 1; EC 2.4.1.83;
Function
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.
Biological Process
Dolichol metabolic process Source: MGI
GDP-mannose metabolic process Source: Ensembl
GPI anchor biosynthetic process Source: UniProtKB
Protein mannosylation Source: HGNC-UCL
Protein O-linked mannosylation Source: HGNC-UCL
Cellular Location
Endoplasmic reticulum
Involvement in disease
Congenital disorder of glycosylation 1E (CDG1E):
A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Some CDG1E patients have features consistent with a dystroglycanopathy and congenital muscular dystrophy, including O-mannosylation defect, camptodactyly, elevated creatine kinase, motor delay and dystrophic changes on muscel biopsy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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