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Mouse Anti-DPP6 Recombinant Antibody (CBYCD-386) (CBMAB-D1597-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCD-386
Antibody Isotype
IgG3, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 715-753 near the C-terminus of human DPPX.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dipeptidyl Peptidase Like 6
Introduction
DPP6 is a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation.
Entrez Gene ID
Human1804
Mouse13483
Rat29272
UniProt ID
HumanP42658
MouseQ9Z218
RatP46101
Alternative Names
Dipeptidyl Peptidase Like 6; Dipeptidyl Peptidase VI; Dipeptidyl-Peptidase 6; Dipeptidyl Peptidase 6; DPP VI; DPPX; Dipeptidyl Aminopeptidase IV-Related Protein; Dipeptidyl Aminopeptidase-Related Protein; Dipeptidyl Aminopeptidase-Like Protein 6;
Function
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354).

Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).
Biological Process
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Familial paroxysmal ventricular fibrillation 2 (VF2):
The disease is caused by variants affecting the gene represented in this entry. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity.
Mental retardation, autosomal dominant 33 (MRD33):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD33 patients manifest microcephaly and intellectual disability.
Topology
Cytoplasmic: 1-95
Helical: 96-116
Extracellular: 117-865
PTM
N-glycosylated.
More Infomation

Chen, T. H., Yang, C. C., Luo, K. H., Dai, C. Y., Chuang, Y. C., & Chuang, H. Y. (2021). The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association. International Journal of Environmental Research and Public Health, 18(19), 10484.

Zhao, X., Cao, D., Ren, Z., Liu, Z., Lv, S., Zhu, J., ... & He, Q. (2020). Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma. Bioscience reports, 40(7).

Demine, S., Garcia Ribeiro, R., Thevenet, J., Marselli, L., Marchetti, P., Pattou, F., ... & Eizirik, D. L. (2020). A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice. Diabetologia, 63(4), 825-836.

Lin, L., Petralia, R. S., Lake, R., Wang, Y. X., & Hoffman, D. A. (2020). A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathologica Communications, 8(1), 1-18.

Naujock, M., Speidel, A., Fischer, S., Kizner, V., Dorner-Ciossek, C., & Gillardon, F. (2020). Neuronal differentiation of induced pluripotent stem cells from schizophrenia patients in two-dimensional and in three-dimensional cultures reveals increased expression of the Kv4. 2 subunit DPP6 that contributes to decreased neuronal activity. Stem cells and development, 29(24), 1577-1587.

Cacace, R., Heeman, B., Van Mossevelde, S., De Roeck, A., Hoogmartens, J., De Rijk, P., ... & Van Broeckhoven, C. (2019). Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta neuropathologica, 137(6), 901-918.

Ding, D. B., Fan, L. L., Xiao, Z., Huang, H., Chen, Y. Q., Guo, S., ... & Xiang, R. (2018). A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation. QJM: An International Journal of Medicine, 111(6), 373-377.

Maussion, G., Cruceanu, C., Rosenfeld, J. A., Bell, S. C., Jollant, F., Szatkiewicz, J., ... & Ernst, C. (2017). Implication of LRRC4C and DPP6 in neurodevelopmental disorders. American Journal of Medical Genetics Part A, 173(2), 395-406.

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For research use only. Not intended for any clinical use.

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