Sign in or Register   Sign in or Register
  |  

Mouse Anti-DPPA2 Recombinant Antibody (CAP648) (CBMAB-AP1940LY)


See all DPPA2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CAP648
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of mouse DPPA2.
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Developmental Pluripotency Associated 2
Introduction
DPPA2 (Developmental Pluripotency Associated 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is DPPA4.
Entrez Gene ID
73703
UniProt ID
Q9CWH0
Alternative Names
Developmental Pluripotency Associated 2; Pluripotent Embryonic Stem Cell-Related Gene 1 Protein; Cancer/Testis Antigen 100; PESCRG1; Embryonic Stem Cell (ESC) Associated Transcript 15-2; Developmental Pluripotency-Associated Protein 2; ECAT15-2; CT100;
Function
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
Biological Process
System development Source: GO_Central
Cellular Location
Nucleus

Carlini, V., Policarpi, C., & Hackett, J. A. (2022). Epigenetic inheritance is gated by naive pluripotency and Dppa2. The EMBO journal, 41(7), e108677.

Li, H., Long, C., Xiang, J., Liang, P., Li, X., & Zuo, Y. (2021). Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region. Briefings in Bioinformatics, 22(4), bbaa342.

Kubinyecz, O., Santos, F., Drage, D., Reik, W., & Eckersley-Maslin, M. A. (2021). Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development, 148(24), dev200191.

Klein, R. H., & Knoepfler, P. S. (2021). DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer. Stem cell reports, 16(12), 2844-2851.

Eckersley-Maslin, M. A., Parry, A., Blotenburg, M., Krueger, C., Ito, Y., Franklin, V. N. R., ... & Reik, W. (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural & Molecular Biology, 27(8), 696-705.

Eckersley-Maslin, M. A. (2020). Keeping your options open: insights from Dppa2/4 into how epigenetic priming factors promote cell plasticity. Biochemical Society Transactions, 48(6), 2891-2902.

Gretarsson, K. H., & Hackett, J. A. (2020). Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development. Nature Structural & Molecular Biology, 27(8), 706-716.

Eckersley-Maslin, M., Alda-Catalinas, C., Blotenburg, M., Kreibich, E., Krueger, C., & Reik, W. (2019). Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program. Genes & development, 33(3-4), 194-208.

Yan, Y. L., Zhang, C., Hao, J., Wang, X. L., Ming, J., Mi, L., ... & Wang, Y. (2019). DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program. PLoS biology, 17(6), e3000324.

De Iaco, A., Coudray, A., Duc, J., & Trono, D. (2019). DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells. EMBO reports, 20(5), e47382.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DPPA2 Recombinant Antibody (CAP648)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare