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Rat Anti-DSC3 Recombinant Antibody (CBYCD-553) (CBMAB-D1721-YC)

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Basic Information

Host Animal
Rat
Clone
CBYCD-553
Application
WB, IHC
Immunogen
Mouse myeloma cell line derived recombinant mouse Desmocollin-3 (Arg136-Leu695).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
desmocollin 3
Introduction
DSC3 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers.
Entrez Gene ID
13507
UniProt ID
P55850
Alternative Names
Desmocollin 3; Cadherin Family Member 3; Desmocollin-4; CDHF3; HT-CP; DSC4;
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Biological Process
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Protein stabilization Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Hypotrichosis and recurrent skin vesicles (HRSV):
A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the body. Mucosal vesicles are absent.
Topology
Extracellular: 136-690
Helical: 691-711
Cytoplasmic: 712-896

Hudemann, C., Maglie, R., Llamazares-Prada, M., Beckert, B., Didona, D., Tikkanen, R., ... & Eming, R. (2022). Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus. Journal of Investigative Dermatology, 142(3), 915-923.

Meltzanidou, P., Patsatsi, A., Kyriakou, A., Vareli, K., & Lambropoulos, A. (2019). Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus. Acta Dermatovenerologica Croatica, 27(1), 8-8.

Ko, H., Hasegawa, H., Ochiai, T., Shimada, K., Roy, R. R., Aizawa, S., & Yamada, H. (2019). Loss of Basal Cell Character in Regenerating Oral Squamous Epithelium with Altered Expression of Desmoglein 1, Desmocollin 3 and Keratin 19. Journal of Hard Tissue Biology, 28(1), 43-50.

Cui, T., Yang, L., Ma, Y., Petersen, I., & Chen, Y. (2019). Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer. Experimental Cell Research, 378(2), 124-130.

Lotti, R., Atene, C. G., Marconi, A., Di Rocco, G., Reggiani Bonetti, L., Zanocco Marani, T., & Pincelli, C. (2019). Development of a desmocollin-3 active mouse model recapitulating human atypical pemphigus. Frontiers in immunology, 1387.

Iranzo, P., Ishii, N., Hashimoto, T., & Alsina‐Gibert, M. (2019). Nonclassical pemphigus with exclusively IgG anti‐desmocollin 3‐specific antibodies. Australasian Journal of Dermatology, 60(3), e217-e219.

Adaszewska, A., Ishii, N., Dwilewicz-Trojaczek, J., Woźniak, K., Hashimoto, T., & Kowalewski, C. (2018). Paraneoplastic pemphigus with anti-desmocollin 3 autoantibodies and chronic lymphocytic leukemia. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 35(1), 113.

Belani, C. P., Chakraborty, B. C., Modi, R. I., & Khamar, B. M. (2017). A randomized trial of TLR-2 agonist CADI-05 targeting desmocollin-3 for advanced non-small-cell lung cancer. Annals of Oncology, 28(2), 298-304.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-DSC3 Recombinant Antibody (4D2) (CAT#: V2LY-0425-LY955)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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