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Mouse Anti-DSE Recombinant Antibody (6D4) (V2LY-0425-LY966)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
6D4
Application
ELISA, WB
Immunogen
DSE (aa574-673) partial recombinant protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Dermatan Sulfate Epimerase
Entrez Gene ID
Human29940
Mouse212898
UniProt ID
HumanQ9UL01
MouseQ8BLI4
Research Area
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Biological Process
Chondroitin sulfate biosynthetic process Source: UniProtKB-UniPathway
Chondroitin sulfate metabolic process Source: GO_Central
Dermatan sulfate biosynthetic process Source: UniProtKB
Dermatan sulfate metabolic process Source: GO_Central
Heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus membrane; Endoplasmic reticulum membrane; Microsome membrane; Cytoplasmic vesicle membrane
Involvement in disease
Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2):
A form of Ehlers-Danlos syndrome characterized by progressive multisystem manifestations, including joint dislocations and deformities, skin hyperextensibility, skin bruisability and fragility with recurrent large subcutaneous hematomas, cardiac valvular, respiratory, gastrointestinal, and ophthalmologic complications. Motor developmental delay is associated with muscle hypoplasia, muscle weakness, and an abnormal muscle fiber pattern in histology in adulthood.
Topology
Lumenal: 23-902
Helical: 903-923
Cytoplasmic: 924-933
Helical: 934-954
Lumenal: 955-958
PTM
N-glycosylated (PubMed:19004833, Ref. 7). Glycosylation is important for enzymatic activity (PubMed:19004833).

Lautrup, C. K., Teik, K. W., Unzaki, A., Mizumoto, S., Syx, D., Sin, H. H., ... & Kosho, T. (2020). Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency. Molecular genetics & genomic medicine, 8(5), e1197.

Schirwani, S., Metcalfe, K., Wagner, B., Berry, I., Sobey, G., & Jewell, R. (2020). DSE associated musculocontractural EDS, a milder phenotype or phenotypic variability. European Journal of Medical Genetics, 63(4), 103798.

Liao, W. C., Yen, H. R., Liao, C. K., Tseng, T. J., Lan, C. T., & Liu, C. H. (2019). DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis. American journal of cancer research, 9(2), 347.

Liao, W. C., Liao, C. K., Tsai, Y. H., Tseng, T. J., Chuang, L. C., Lan, C. T., ... & Liu, C. H. (2018). DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. PLoS One, 13(6), e0198364.

Gouignard, N., Schön, T., Holmgren, C., Strate, I., Taşöz, E., Wetzel, F., ... & Pera, E. M. (2018). Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo. Plos one, 13(1), e0191751.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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