Mouse Anti-DSE Recombinant Antibody (6D4) (V2LY-0425-LY966)

Name: Mouse Anti-DSE Recombinant Antibody (6D4)
SKU: V2LY-0425-LY966
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

6D4

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

DSE (aa574-673) partial recombinant protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Dermatan Sulfate Epimerase

Entrez Gene ID

Human	29940
Mouse	212898

UniProt ID

Human	Q9UL01
Mouse	Q8BLI4

Research Area

Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.

Biological Process

Chondroitin sulfate biosynthetic process Source: UniProtKB-UniPathway
Chondroitin sulfate metabolic process Source: GO_Central
Dermatan sulfate biosynthetic process Source: UniProtKB
Dermatan sulfate metabolic process Source: GO_Central
Heparan sulfate proteoglycan biosynthetic process Source: UniProtKB-UniPathway

Cellular Location

Golgi apparatus membrane; Endoplasmic reticulum membrane; Microsome membrane; Cytoplasmic vesicle membrane

Involvement in disease

Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2):
A form of Ehlers-Danlos syndrome characterized by progressive multisystem manifestations, including joint dislocations and deformities, skin hyperextensibility, skin bruisability and fragility with recurrent large subcutaneous hematomas, cardiac valvular, respiratory, gastrointestinal, and ophthalmologic complications. Motor developmental delay is associated with muscle hypoplasia, muscle weakness, and an abnormal muscle fiber pattern in histology in adulthood.

Topology

Lumenal: 23-902
Helical: 903-923
Cytoplasmic: 924-933
Helical: 934-954
Lumenal: 955-958

PTM

N-glycosylated (PubMed:19004833, Ref. 7). Glycosylation is important for enzymatic activity (PubMed:19004833).

More Infomation

References

Lautrup, C. K., Teik, K. W., Unzaki, A., Mizumoto, S., Syx, D., Sin, H. H., ... & Kosho, T. (2020). Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency. Molecular genetics & genomic medicine, 8(5), e1197.

Schirwani, S., Metcalfe, K., Wagner, B., Berry, I., Sobey, G., & Jewell, R. (2020). DSE associated musculocontractural EDS, a milder phenotype or phenotypic variability. European Journal of Medical Genetics, 63(4), 103798.

Liao, W. C., Yen, H. R., Liao, C. K., Tseng, T. J., Lan, C. T., & Liu, C. H. (2019). DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis. American journal of cancer research, 9(2), 347.

Liao, W. C., Liao, C. K., Tsai, Y. H., Tseng, T. J., Chuang, L. C., Lan, C. T., ... & Liu, C. H. (2018). DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. PLoS One, 13(6), e0198364.

Gouignard, N., Schön, T., Holmgren, C., Strate, I., Taşöz, E., Wetzel, F., ... & Pera, E. M. (2018). Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo. Plos one, 13(1), e0191751.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DSE Recombinant Antibody (6D4)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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