Mouse Anti-DTD1 Recombinant Antibody (1E1) (CBMAB-D1831-YC)

Name: Mouse Anti-DTD1 Recombinant Antibody (1E1)
SKU: CBMAB-D1831-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E1

Application

IF, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

D-Tyrosyl-TRNA Deacylase 1

Introduction

DTD1 is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

92675

UniProt ID

Q8TEA8

Alternative Names

D-Tyrosyl-TRNA Deacylase 1; DNA-Unwinding Element-Binding Protein B; Histidyl-TRNA Synthase-Related; Gly-TRNA(Ala) Deacylase; C20orf88; HARS2; DUE-B; DUEB; DTD; D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae);

Research Area

Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Biological Process

DNA replication Source: UniProtKB-KW
tRNA metabolic process Source: GO_Central

Cellular Location

Nucleus; Cytoplasm. Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).

PTM

Preferentially phosphorylated in cells arrested early in S phase (PubMed:15653697). Phosphorylation in the C-terminus weakens the interaction with CDC45 (PubMed:20065034).

Mazeed, M., Singh, R., Kumar, P., Roy, A., Raman, B., Kruparani, S. P., & Sankaranarayanan, R. (2021). Recruitment of archaeal DTD is a key event toward the emergence of land plants. Science Advances, 7(6), eabe8890.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DTD1 Recombinant Antibody (1E1) (CAT#: V2LY-0425-LY1024)

Related Products

Mouse Anti-DTD1 Recombinant Antibody (1E1) (CAT#: V2LY-0425-LY1024)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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