Sign in or Register   Sign in or Register
  |  

Mouse Anti-DTD1 Recombinant Antibody (1E1) (CBMAB-D1831-YC)

Provided herein is a Mouse monoclonal antibody, which binds to D-Tyrosyl-TRNA Deacylase 1 (DTD1). The antibody can be used for immunoassay techniques, such as IF, WB.
See all DTD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E1
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
D-Tyrosyl-TRNA Deacylase 1
Introduction
DTD1 is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
92675
UniProt ID
Q8TEA8
Alternative Names
D-Tyrosyl-TRNA Deacylase 1; DNA-Unwinding Element-Binding Protein B; Histidyl-TRNA Synthase-Related; Gly-TRNA(Ala) Deacylase; C20orf88; HARS2; DUE-B; DUEB; DTD; D-Tyrosyl-TRNA Deacylase 1 Homolog (S. Cerevisiae);
Research Area
Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Biological Process
DNA replication Source: UniProtKB-KW
tRNA metabolic process Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
PTM
Preferentially phosphorylated in cells arrested early in S phase (PubMed:15653697). Phosphorylation in the C-terminus weakens the interaction with CDC45 (PubMed:20065034).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DTD1 Recombinant Antibody (1E1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare