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Mouse Anti-DYNLT1 Recombinant Antibody (7A9-F4-H10) (CBMAB-D2010-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynein Light Chain Tctex-Type 1 (DYNLT1). The antibody can be used for immunoassay techniques, such as WB, IF.
See all DYNLT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
7A9-F4-H10
Antibody Isotype
IgG1, κ
Application
WB, IF

Basic Information

Immunogen
Full-length recombinant human DYNLT1 protein
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Light Chain Tctex-Type 1
Introduction
DYNLT1 the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation.
Entrez Gene ID
Human6993
Rat83462
UniProt ID
HumanP63172
RatQ9Z336
Alternative Names
Dynein Light Chain Tctex-Type 1; T-Complex-Associated-Testis-Expressed 1-Like 1; T-Complex Testis-Specific Protein 1 Homolog; Tctex-1; TCTEL1; Protein CW-1; TCTEX1; CW-1;
Research Area
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.

Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).

Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).

(Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.
Biological Process
Axon development Source: Ensembl
Cell division Source: UniProtKB-KW
Dendrite development Source: Ensembl
Establishment of mitotic spindle orientation Source: UniProtKB
Intracellular transport of viral protein in host cell Source: UniProtKB
Microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-KW
Negative regulation of cell death Source: Ensembl
Negative regulation of mitochondrial membrane permeability Source: Ensembl
Negative regulation of neurogenesis Source: UniProtKB
Neuron projection morphogenesis Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of Rac protein signal transduction Source: Ensembl
Regulation of cytoskeleton organization Source: Ensembl
Regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
Regulation of GTPase activity Source: Ensembl
Viral entry into host cell Source: UniProtKB-KW
Cellular Location
Spindle; Golgi apparatus; Cytoplasm. Localizes to mitotic spindles.
PTM
Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIMi:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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