Rabbit Anti-LPAR2 Recombinant Antibody (EG1026) (CBMAB-EN1210-LY)

Name: Rabbit Anti-LPAR2 Recombinant Antibody (EG1026)
SKU: CBMAB-EN1210-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1026

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human EDG4.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lysophosphatidic acid receptor 2

Introduction

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.

Entrez Gene ID

Human	9170
Mouse	53978

UniProt ID

Human	Q9HBW0
Mouse	Q9JL06

Alternative Names

EDG4; LPA2; EDG-4; LPA-2

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

Biological Process

Activation of phospholipase C activityManual Assertion Based On ExperimentTAS:ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell surface
Cell membrane
Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Topology

Extracellular: 1-30
Helical: 31-51
Cytoplasmic: 52-66
Helical: 67-87
Extracellular: 88-100
Helical: 101-123
Cytoplasmic: 124-143
Helical: 144-164
Extracellular: 165-185
Helical: 186-206
Cytoplasmic: 207-239
Helical: 240-260
Extracellular: 261-276
Helical: 277-294
Cytoplasmic: 295-348

Hutka, B., Várallyay, A., László, S. B., Tóth, A. S., Scheich, B., Paku, S., ... & Zádori, Z. S. (2023). A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy. Acta Pharmacologica Sinica, 1-15.

Ren, G., Guo, J. H., Feng, C. L., Ding, Y. W., Dong, B., Han, Y. X., ... & Jiang, J. D. (2022). Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model. Molecular Therapy-Oncolytics, 26, 372-386.

Ara, H., Bhattarai, S., Sharma, S., Subedi, U., Yu, X., Bhuiyan, M. S., ... & Panchatcharam, M. (2022). LPAR2 receptor stimulates progression of gastric cancer through β‐catenin signaling pathway. The FASEB Journal, 36.

Ara, H., Subedi, U., Sharma, P., Bhattarai, S., Sharma, S., Manikandan, S., ... & Panchatcharam, M. (2022). Alteration of Cellular Energy Metabolism through LPAR2-Axin2 Axis in Gastric Cancer. Biomolecules, 12(12), 1805.

Fischer, C., Endle, H., Schumann, L., Wilken-Schmitz, A., Kaiser, J., Gerber, S., ... & Tegeder, I. (2021). Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2. Cellular and Molecular Life Sciences, 78, 1029-1050.

Ara, H., Bhattarai, S., Sharma, S., Subedi, U., Bhuiyan, M. S., Yu, X., ... & Panchatcharam, M. (2021). Lysophosphatidic acid's unknown role in the initiation and progression of gastric cancer through LPAR2 receptor and beta-catenin signaling pathway by altering the energy metabolism. Cancer Research, 81(13_Supplement), 1987-1987.

Kim, M., Sur, B., Villa, T., Yun, J., Nah, S. Y., & Oh, S. (2021). Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2. Journal of Ginseng Research, 45(5), 575-582.

Shukla, P. K., Meena, A. S., Gangwar, R., Szabo, E., Balogh, A., Lee, S. C., ... & Rao, R. (2020). LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 34(9), 11641.

Kowalczyk-Zieba, I., Woclawek-Potocka, I., Wasniewski, T., Boruszewska, D., Grycmacher, K., Sinderewicz, E., ... & Wolczynski, S. (2019). LPAR2 and LPAR4 are the main receptors responsible for LPA actions in ovarian endometriotic cysts. Reproductive Sciences, 26(1), 139-150.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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