LPAR2

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.

Full Name

lysophosphatidic acid receptor 2

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

Biological Process

Activation of phospholipase C activityManual Assertion Based On ExperimentTAS:ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell surface
Cell membrane
Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Topology

Extracellular: 1-30
Helical: 31-51
Cytoplasmic: 52-66
Helical: 67-87
Extracellular: 88-100
Helical: 101-123
Cytoplasmic: 124-143
Helical: 144-164
Extracellular: 165-185
Helical: 186-206
Cytoplasmic: 207-239
Helical: 240-260
Extracellular: 261-276
Helical: 277-294
Cytoplasmic: 295-348