Mouse Anti-EDNRA Recombinant Antibody (E0770) (V2LY-0425-LY1413)

Name: Mouse Anti-EDNRA Recombinant Antibody (E0770)
SKU: V2LY-0425-LY1413
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

E0770

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 21-80 mapping within an N-terminal extracellular domain of human ETAR.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

endothelin receptor type A

Entrez Gene ID

Human	1909
Mouse	13617

UniProt ID

Human	P25101
Mouse	Q61614

Research Area

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1> ET2>> ET3.

Biological Process

Activation of adenylate cyclase activity Source: ProtInc
Activation of phospholipase C activity Source: ProtInc
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
Artery smooth muscle contraction Source: BHF-UCL
Branching involved in blood vessel morphogenesis Source: Ensembl
Cell population proliferation Source: ProtInc
Enteric nervous system development Source: InterPro
G protein-coupled receptor signaling pathway Source: UniProtKB
Head development Source: Ensembl
Heart development Source: Ensembl
In utero embryonic development Source: Ensembl
Neural crest cell development Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Regulation of blood pressure Source: InterPro
Regulation of glucose transmembrane transport Source: Ensembl
Respiratory gaseous exchange by respiratory system Source: UniProtKB
Response to hypoxia Source: Ensembl
Signal transduction Source: ProtInc
Smooth muscle contraction Source: ProtInc
Vasoconstriction Source: BHF-UCL

Cellular Location

Cell membrane

Involvement in disease

Mandibulofacial dysostosis with alopecia (MFDA):
A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility.

Topology

Extracellular: 21-80
Helical: 81-102
Cytoplasmic: 103-112
Helical: 113-132
Extracellular: 133-159
Helical: 160-181
Cytoplasmic: 182-205
Helical: 206-229
Extracellular: 230-256
Helical: 257-278
Cytoplasmic: 279-306
Helical: 307-328
Extracellular: 329-347
Helical: 348-372
Cytoplasmic: 373-427

Pan, Z., Chen, Q., Ding, H., & Li, H. (2022). MicroRNA-342-3p loaded by human umbilical cord mesenchymal stem cells-derived exosomes attenuates deep vein thrombosis by downregulating EDNRA. Journal of Thrombosis and Thrombolysis, 1-9.

Zhou, W., Xi, D., Shi, Y., Wang, L., Zhong, H., Huang, Z., ... & He, F. (2021). MicroRNA‑1929‑3p participates in murine cytomegalovirus‑induced hypertensive vascular remodeling through Ednra/NLRP3 inflammasome activation Corrigendum in/10.3892/ijmm. 2022.5082. international journal of molecular medicine, 47(2), 719-731.

Wang, Y., Huang, Z., Zhong, H., Wang, L., Xi, D., Shi, Y., ... & He, F. (2020). Mir-1929-3p overexpression alleviates murine cytomegalovirus-induced hypertensive myocardial remodeling by suppressing ednra/nlrp3 inflammasome activation. BioMed Research International, 2020.

Zeng, Y., Chen, R., Ma, M., Liu, B., Xia, J., Xu, H., ... & Zhang, L. (2019). Associations of EDNRA and EDNRB polymorphisms with intracerebral hemorrhage. World Neurosurgery, 129, e472-e477.

Minchenko, D. O., Tsymbal, D. O., Riabovol, O. O., Viletska, Y. M., Lahanovska, Y. O., Sliusar, M. Y., ... & Minchenko, O. H. (2019). Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells. Endocrine regulations, 53(4), 250-262.

Liu, H., Luo, Q., Zhang, J., Mo, C., Wang, Y., & Li, J. (2019). Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution. General and comparative endocrinology, 283, 113231.

Wei, W., Shi, L., Chen, W., Hu, L., Chen, D., Shi, X., ... & Wu, Z. (2018). miR-200c regulates the proliferation, apoptosis and invasion of gastric carcinoma cells through the downregulation of EDNRA expression. International journal of molecular medicine, 41(3), 1619-1626.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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