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Mouse Anti-EFHD2 Recombinant Antibody (CBFYE-0479) (CBMAB-E0826-FY)

This product is mouse antibody that recognizes EFHD2. The antibody CBFYE-0479 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all EFHD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0479
Antibody Isotype
IgG2b
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EF-Hand Domain Family Member D2
Introduction
EFHD2 (EF-Hand Domain Family Member D2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EFHD1.
Entrez Gene ID
79180
UniProt ID
Q96C19
Alternative Names
EF-Hand Domain Family Member D2; EF Hand Domain Containing 2; Swiprosin-1; SWS1; EF-Hand Domain-Containing Protein D2; Testicular Tissue Protein Li 62; Swiprosin 1
Research Area
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Cellular Location
Membrane raft. In a mouse immature B-cell line WEHI-231.

Lehne, F., Pokrant, T., Parbin, S., Salinas, G., Großhans, J., Rust, K., ... & Bogdan, S. (2022). Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. Nature communications, 13(1), 1-17.

Wang, Y., Song, M., & Gao, B. (2022). EF-Hand Domain-Containing Protein D2 (EFHD2) Correlates with Immune Infiltration and Predicts the Prognosis of Patients: A Pan-Cancer Analysis. Computational and Mathematical Methods in Medicine, 2022.

Soliman, A. S., Umstead, A., Grabinski, T., Kanaan, N. M., Lee, A., Ryan, J., ... & Vega, I. E. (2021). EFhd2 brain interactome reveals its association with different cellular and molecular processes. Journal of Neurochemistry, 159(6), 992-1007.

Gao, M., Zeng, K., Li, Y., Liu, Y. P., Xia, X., Xu, F. L., ... & Wang, B. J. (2020). Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China. Journal of International Medical Research, 48(6), 0300060520932801.

Fan, C. C., Tsai, S. T., Lin, C. Y., Chang, L. C., Yang, J. C., Chen, G. Y., ... & Chang, W. C. (2020). EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis. Redox biology, 34, 101571.

Kogias, G., Zheng, F., Kalinichenko, L. S., Kornhuber, J., Alzheimer, C., Mielenz, D., & Müller, C. P. (2020). Swiprosin1/EFhd2 is involved in the monoaminergic and locomotor responses of psychostimulant drugs. Journal of Neurochemistry, 154(4), 424-440.

Vega, I. E., Umstead, A., & Kanaan, N. M. (2019). EFhd2 Affects Tau Liquid–Liquid Phase Separation. Frontiers in Neuroscience, 13, 845.

Huh, Y. H., Yeo, Y. R., & Song, W. K. (2019). Three-Dimensional Reconstruction Imaging Method to Study the Function of EFHD2 in Invadopodia Formation. In Calcium-Binding Proteins of the EF-Hand Superfamily (pp. 607-613). Humana Press, New York, NY.

Tu, Y., Zhang, L., Tong, L., Wang, Y., Zhang, S., Wang, R., ... & Wang, Z. (2018). EFhd2/swiprosin-1 regulates LPS-induced macrophage recruitment via enhancing actin polymerization and cell migration. International Immunopharmacology, 55, 263-271.

Mielenz, D., Reichel, M., Jia, T., Quinlan, E. B., Stöckl, T., Mettang, M., ... & Mueller, C. P. (2018). EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. Molecular psychiatry, 23(5), 1303-1319.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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