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Rabbit Anti-EIF1AX Recombinant Antibody (CBFYE-0635) (CBMAB-E1041-FY)

This product is rabbit antibody that recognizes EIF1AX. The antibody CBFYE-0635 can be used for immunoassay techniques such as: WB, IP, IHC-P, IF.
See all EIF1AX antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBFYE-0635
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 1A, X-Linked
Introduction
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
Entrez Gene ID
Human1964
Mouse66235
Rat302697
UniProt ID
HumanP47813
MouseQ8BMJ3
RatB5DF60
Alternative Names
Eukaryotic Translation Initiation Factor 1A, X-Linked; Eukaryotic Translation Initiation Factor 1A, X Chromosome; Eukaryotic Translation Initiation Factor 4C; EIF-1A X Isoform; EIF-4C; EIF1A
Research Area
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
Biological Process
Translational initiation Source: ProtInc
Cellular Location
Cytosol

French, E. K., Nikitski, A. V., Yip, L., Nikiforova, M. N., Nikiforov, Y. E., & Carty, S. E. (2022). Clinicopathological features and outcomes of thyroid nodules with EIF1AX mutations. Endocrine-Related Cancer, 1(aop).

Zhang, Q., Li, W., Feng, P., Liu, Y., Chu, B., Zhao, J., ... & Liu, J. (2022). Lnc5926 is essential for early embryonic development in goats through regulation of ZSCAN4 and EIF1AX. Theriogenology, 180, 87-93.

Lv, C., Sun, J., Ye, Y., Lin, Z., Li, H., Liu, Y., ... & Wang, S. (2022). Long noncoding RNA EIF1AX‐AS1 promotes endometrial cancer cell apoptosis by affecting EIF1AX mRNA stabilization. Cancer science, 113(4), 1277.

Li, Y., Guo, L., Ying, S., Feng, G. H., & Zhang, Y. (2020). Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Proliferation, 53(10), e12903.

Hou, C., Xiao, L., Ren, X., Tang, F., Guo, B., Zeng, W., ... & Yan, N. (2020). Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal melanoma in Chinese patients. Ophthalmic research, 63(3), 358-368.

Krishnamoorthy, G. P., Davidson, N. R., Leach, S. D., Zhao, Z., Lowe, S. W., Lee, G., ... & Fagin, J. A. (2019). EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYCEIF1AX and RAS Cooperate to Generate mTOR Kinase Dependency0000-0002-5284-9650. Cancer discovery, 9(2), 264-281.

Simões-Pereira, J., Moura, M. M., Marques, I. J., Rito, M., Cabrera, R. A., Leite, V., & Cavaco, B. M. (2019). The role of EIF1AX in thyroid cancer tumourigenesis and progression. Journal of Endocrinological Investigation, 42(3), 313-318.

Alzahrani, A. S., Murugan, A. K., Qasem, E., Alswailem, M. M., AlGhamdi, B., Moria, Y., & Al-Hindi, H. (2019). Absence of EIF1AX, PPM1D, and CHEK2 mutations reported in Thyroid Cancer Genome Atlas (TCGA) in a large series of thyroid cancer. Endocrine, 63(1), 94-100.

Topf, M. C., Wang, Z. X., Tuluc, M., & Pribitkin, E. A. (2018). TERT, HRAS, and EIF1AX Mutations in a Patient with Follicular Adenoma. Thyroid, 28(6), 815-817.

Rose, A. M., Luo, R., Radia, U. K., Kalirai, H., Thornton, S., Luthert, P. J., ... & Rose, G. E. (2018). Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis. BMC cancer, 18(1), 1-9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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